Department of Immunogenetics, National Blood Transfusion Center, Tunis, Tunisia.
Research and Production Center of Transfusion, Kazakhstan Ministry of Health, Astana, Kazakhstan.
HLA. 2021 Dec;98(6):525-535. doi: 10.1111/tan.14377. Epub 2021 Nov 28.
The present-day population of Kazakhstan comprises more than 100 ethnic and linguistic groups, of which Ukrainians rates numerically as the fourth, following native Kazakhs, Russians, and Uzbeks. We investigated the HLA profile of Kazakhstani Ukrainians and compared them with those of other populations by applying genetic distances, correspondence analysis, admixture, and haplotype examination. Of the 128 HLA alleles identified, A02:01 (28.64%), B07:02 (9.71%), B13:02 (9.71%), C06:02 (15.05%), DRB107:01 (15.20%), and DQB103:01 (24.76%) were the utmost common alleles. The most common 2-locus haplotypes identified were A02:01 ~ B13:02 (6.66%), B13:02 ~ DRB107:01 (6.57%), B13:02 ~ C06:02 (10.10%), and DRB101:01 ~ DQB105:01 (12.12%), while A02:01 ~ B13:02 ~ C06:02 ~ DRB107:01 ~ DQB1*02:01 were the most frequent five-locus haplotype (4.04%) in Kazakhstani Ukrainians. Comparative analysis revealed that Ukrainians of Kazakhstan are closely related to Eastern Europeans (included Ukrainians), and European Russians, but distant from Asian populations. This supports the historical notion that Kazakhstani Ukrainians originated from Ukraine, following their massive migrations to central Asia in the 18th-20th centuries.
哈萨克斯坦的现代人口由 100 多个民族和语言群体组成，其中乌克兰人在数量上排名第四，仅次于哈萨克人、俄罗斯人和乌兹别克人。我们通过遗传距离、对应分析、混合和单倍型分析研究了哈萨克斯坦乌克兰人的 HLA 图谱，并将其与其他人群进行了比较。在所确定的 128 个 HLA 等位基因中，A02:01（28.64%）、B07:02（9.71%）、B13:02（9.71%）、C06:02（15.05%）、DRB107:01（15.20%）和 DQB103:01（24.76%）是最常见的等位基因。最常见的 2 个位点单倍型是 A02:01~B13:02（6.66%）、B13:02~DRB107:01（6.57%）、B13:02~C06:02（10.10%）和 DRB101:01~DQB105:01（12.12%），而 A02:01~B13:02C*06:02DRB107:01~DQB102:01 是哈萨克斯坦乌克兰人中最常见的 5 个位点单倍型（4.04%）。比较分析表明，哈萨克斯坦的乌克兰人与东欧人（包括乌克兰人）和俄罗斯欧洲人关系密切，但与亚洲人群关系较远。这支持了一个历史观点，即哈萨克斯坦的乌克兰人起源于乌克兰，他们在 18 至 20 世纪大规模移民到中亚。
