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人类感染 SARS-CoV-2 后针对刺突蛋白和核衣壳蛋白的血清学反应。

Human post-infection serological response to the spike and nucleocapsid proteins of SARS-CoV-2.

机构信息

Guangzhou Medical University, Guangzhou, China.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, China.

出版信息

Influenza Other Respir Viruses. 2021 Jan;15(1):7-12. doi: 10.1111/irv.12798. Epub 2020 Aug 25.

DOI:10.1111/irv.12798
PMID:32844604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7461388/
Abstract

To inform seroepidemiological studies, we characterized the IgG- responses in COVID-19 patients against the two major SARS-CoV-2 viral proteins, spike (S) and nucleocapsid (N). We tested 70 COVID-19 sera collected up to 85 days post-symptom onset and 230 non-COVID-19 sera, including 27 SARS sera from 2003. Although the average SARS-CoV-2 S and N-IgG titers were comparable, N-responses were more variable among individuals. S- and N-assay specificity tested with non-COVID-19 sera were comparable at 97.5% and 97.0%, respectively. Therefore, S will make a better target due to its lower cross-reactive potential and its' more consistent frequency of detection compared to N.

摘要

为了为血清流行病学研究提供信息，我们针对两种主要的 SARS-CoV-2 病毒蛋白（刺突蛋白[S]和核衣壳蛋白[N]）对 COVID-19 患者的 IgG 反应进行了特征描述。我们检测了 70 份发病后 85 天内采集的 COVID-19 血清和 230 份非 COVID-19 血清，其中包括 2003 年的 27 份 SARS 血清。尽管 SARS-CoV-2 的 S 和 N-IgG 滴度平均值相当，但 N 反应在个体之间的变异性更大。用非 COVID-19 血清检测的 S 和 N 检测的特异性分别为 97.5%和 97.0%。因此，与 N 相比，S 由于其较低的交叉反应潜力和更一致的检测频率，将成为更好的靶标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/7767953/81f2e82525ce/IRV-15-7-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/7767953/d4b03fa7cc1c/IRV-15-7-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/7767953/c61d52218ef0/IRV-15-7-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/7767953/81f2e82525ce/IRV-15-7-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/7767953/d4b03fa7cc1c/IRV-15-7-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/7767953/c61d52218ef0/IRV-15-7-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/7767953/81f2e82525ce/IRV-15-7-g003.jpg

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本文引用的文献

1
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J Clin Virol. 2020 Aug;129:104468. doi: 10.1016/j.jcv.2020.104468. Epub 2020 May 23.
2
Longitudinal Change of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in Patients with Coronavirus Disease 2019.新型冠状病毒病患者严重急性呼吸综合征冠状病毒 2 抗体的纵向变化。
J Infect Dis. 2020 Jun 29;222(2):183-188. doi: 10.1093/infdis/jiaa229.
3
Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients.
Influenza Other Respir Viruses. 2021 Jul;15(4):552-553. doi: 10.1111/irv.12852. Epub 2021 Mar 14.
新型冠状病毒肺炎患者中 SARS-CoV-2 特异性 IgM 和 IgG 反应的动力学。
Emerg Microbes Infect. 2020 Dec;9(1):940-948. doi: 10.1080/22221751.2020.1762515.
4
Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020.2020 年 3 月用于严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的血清学检测。
Euro Surveill. 2020 Apr;25(16). doi: 10.2807/1560-7917.ES.2020.25.16.2000421.
5
Profile of Immunoglobulin G and IgM Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的免疫球蛋白G和IgM抗体概况
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6
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Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Patients.严重急性呼吸综合征冠状病毒 2 特异性抗体反应在冠状病毒疾病患者中。
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Antibodies to coronaviruses are higher in older compared with younger adults and binding antibodies are more sensitive than neutralizing antibodies in identifying coronavirus-associated illnesses.与年轻人相比，老年人的冠状病毒抗体水平更高，结合抗体在识别冠状病毒相关疾病方面比中和抗体更敏感。
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9
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JCI Insight. 2019 Feb 21;4(4). doi: 10.1172/jci.insight.123158.