Silengo L, Altruda F, Dotto G P, Lacquaniti F, Perlo C, Turco E, Mangiarotti G
Ital J Biochem. 1977 Mar-Apr;26(2):133-43.
In vivo and in vitro experiments have shown that processing of ribosomal RNA is a late event in ribosome biogenesis. The precursor form of RNA is probably necessary to speed up the assembly of ribomal proteins. Newly formed ribosomal particles which have already entered polyribosomes differ from mature ribosomes not only in their RNA content but also in their susceptibility to unfolding in low Mg concentration and to RNase attack. Final maturation of new ribosomes is probably dependent on their functioning in protein synthesis. Thus only those ribosomes which have proven to be functional may be converted into stable cellular structures.
体内和体外实验表明，核糖体RNA的加工是核糖体生物合成中的一个晚期事件。RNA的前体形式可能对于加速核糖体蛋白的组装是必要的。已经进入多核糖体的新形成的核糖体颗粒不仅在RNA含量上与成熟核糖体不同，而且在低镁浓度下对解折叠和对核糖核酸酶攻击的敏感性方面也不同。新核糖体的最终成熟可能取决于它们在蛋白质合成中的功能。因此，只有那些已被证明具有功能的核糖体才能转化为稳定的细胞结构。
