Research Group of Advanced Ophthalmic Bionic Interface Materials & Drug Delivery, School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
J Mater Chem B. 2020 Nov 18;8(44):10087-10092. doi: 10.1039/d0tb01508c.
Corneal infection is an important cause of corneal damage and vision loss. In this work, polyhydroxy antibiotics were grafted onto polymer brush-modified contact lenses through dynamic chemical bonds between polyphenolic hydroxyls and phenylboronic acid. Both in vitro and in vivo antibacterial tests demonstrated great promise in the prevention of bacterial keratitis, which could be attributed to the enhanced retention time and drug bioavailability.
角膜感染是导致角膜损伤和视力丧失的重要原因。在这项工作中，通过多酚羟基与苯硼酸之间的动态化学键，将多羟基抗生素接枝到聚合物刷修饰的隐形眼镜上。体外和体内抗菌试验均表明，这种方法在预防细菌性角膜炎方面具有很大的潜力，这可以归因于延长了药物的滞留时间和提高了药物的生物利用度。
