Bartholomay Lyric C
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, United States.
Curr Opin Insect Sci. 2014 Sep;3:37-42. doi: 10.1016/j.cois.2014.08.006. Epub 2014 Aug 15.
As a function of size, migration trajectory through the body and developmental site, filarial worm parasites inflict significant damage on the mosquito host. Some mosquitoes are equipped with physical and physiological barriers that confer a refractory state to parasite infection. In a susceptible host, parasites migrate to a developmental site and achieve an intracellular existence; during this process, worms elicit canonical mosquito immune response elements, particularly melanization and antimicrobial peptide (AMP) production. It is clear now that the response to infection also involves mitigating stress and manipulation of host cell machinery to delay necrosis. This review focuses on mechanisms of refractoriness and resistance to Brugia malayi, Brugia pahangi, and Dirofilaria immitis, with emphasis on infection in the mosquito, Aedes aegypti.
作为大小、在宿主体内的迁移轨迹以及发育部位的函数，丝虫寄生虫会对蚊子宿主造成严重损害。一些蚊子具备物理和生理屏障，使其对寄生虫感染呈现难治状态。在易感宿主中，寄生虫迁移到发育部位并实现细胞内生存；在此过程中，蠕虫引发典型的蚊子免疫反应元件，特别是黑化作用和抗菌肽（AMP）的产生。现在很清楚，对感染的反应还涉及减轻压力和操纵宿主细胞机制以延迟坏死。本综述重点关注对马来布鲁线虫、彭亨布鲁线虫和犬恶丝虫的难治性和抗性机制，重点是埃及伊蚊中的感染情况。
