Winkelmann R K, Reizner G T
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905.
Hum Pathol. 1988 Apr;19(4):389-93. doi: 10.1016/s0046-8177(88)80486-6.
Twenty-three cases of diffuse dermal neutrophilia and urticaria were reviewed. Evidence of vasculitis or other disease was not present. Direct immunofluorescence was done in 19 cases and was positive but nonspecific in 14. The presence of angioedema (10 cases), dermographism (2 cases), atopy (4 cases), drug reactions (6 cases), and infections (6 cases) was similar to that seen in cases of urticaria without diffuse dermal neutrophilia. Nearly 9% of the cases of urticaria show this histologic pattern, and when cases of neutrophilic urticaria are added, 15.8% of cases of urticaria were found to show a major neutrophil component in the inflammation. In urticaria, neutrophilia may be part of an intense stimulus response pattern.
对23例弥漫性皮肤嗜中性粒细胞增多症和荨麻疹病例进行了回顾。未发现血管炎或其他疾病的证据。19例进行了直接免疫荧光检查，其中14例呈阳性但非特异性。血管性水肿（10例）、皮肤划痕症（2例）、特应性（4例）、药物反应（6例）和感染（6例）的存在情况与无弥漫性皮肤嗜中性粒细胞增多症的荨麻疹病例相似。近9%的荨麻疹病例呈现这种组织学模式，若将嗜中性粒细胞性荨麻疹病例纳入计算，发现15.8%的荨麻疹病例在炎症中显示主要的嗜中性粒细胞成分。在荨麻疹中，嗜中性粒细胞增多可能是强烈刺激反应模式的一部分。
