Farmer Brandon C, Walsh Adeline E, Kluemper Jude C, Johnson Lance A
Department of Physiology, University of Kentucky, Lexington, KY, United States.
Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, United States.
Front Neurosci. 2020 Jul 29;14:742. doi: 10.3389/fnins.2020.00742. eCollection 2020.
Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to dynamic and functionally active organelles involved in a variety of cellular functions. Studies have now informed significant roles for LDs in cellular signaling, metabolic disease, and inflammation. While lipid droplet biology has been well explored in peripheral organs such as the liver and heart, LDs within the brain are relatively understudied. The presence and function of these dynamic organelles in the central nervous system has recently gained attention, especially in the context of neurodegeneration. In this review, we summarize the current understanding of LDs within the brain, with an emphasis on their relevance in neurodegenerative diseases.
对脂滴（LDs）的认识已从简单的脂质储存库发展为参与多种细胞功能的动态且具有功能活性的细胞器。目前的研究表明，脂滴在细胞信号传导、代谢性疾病和炎症中发挥着重要作用。虽然脂滴生物学在肝脏和心脏等外周器官中已得到充分研究，但大脑中的脂滴相对较少被研究。这些动态细胞器在中枢神经系统中的存在和功能最近受到了关注，尤其是在神经退行性变的背景下。在这篇综述中，我们总结了目前对大脑中脂滴的认识，重点强调它们在神经退行性疾病中的相关性。
