Tavares Gabriel Araujo, Torres Amada, de Souza Julliet Araujo
Nantes Université, INRAE, UMR 1280, PhAN, Nantes, France.
Laboratory of Neuroplasticity and Behavior, Graduate Program of Nutrition, Federal University of Pernambuco, Recife, Brazil.
Front Physiol. 2020 Jul 28;11:925. doi: 10.3389/fphys.2020.00925. eCollection 2020.
Healthy persons hold a very complex system for controlling energy homeostasis. The system functions on the interconnected way between the nutritional, endocrine, neural, and epigenetic regulation, which includes the microRNAs (miRNAs). Currently, it is well accepted that experiences of early life stress (ELS) carry modification of the central control of feeding behavior, one of the factors controlling energy homeostasis. Recently, studies give us a clue on the modulation of eating behavior, which is one of the main factors associated with the development of obesity. This clue connected the neural control through the serotonin (5HT) and dopamine (DA) systems with the fine regulation of miRNAs. The first pieces of evidence highlight the presence of the miR-16 in the regulation of the serotonin transporter (SERT) as well as the receptors 1a (5HT1A) and 2a (5HT2A). On the other hand, miR-504 is related to the dopamine receptor D2 (DRD2). As our knowledge advance, we expected to discover other important pathways for the regulation of the energy homeostasis. As both neurotransmission systems and miRNAs seem to be sensible to ELS, the aim of this review is to bring new insight about the involvement of miRNAs with a central role in the control of eating behavior focusing on the influences of ELS and regulation of neurotransmission systems.
健康个体拥有一个非常复杂的能量稳态控制系统。该系统通过营养、内分泌、神经和表观遗传调控（包括微小RNA（miRNA））之间的相互联系来发挥作用。目前，人们普遍认为早期生活应激（ELS）经历会改变进食行为的中枢控制，而进食行为是控制能量稳态的因素之一。最近，研究为饮食行为的调节提供了线索，饮食行为是与肥胖发展相关的主要因素之一。这条线索将通过血清素（5HT）和多巴胺（DA）系统的神经控制与miRNA的精细调节联系起来。首批证据突出了miR-16在血清素转运体（SERT）以及受体1a（5HT1A）和2a（5HT2A）调节中的存在。另一方面，miR-504与多巴胺受体D2（DRD2）相关。随着我们知识的进步，我们期望发现其他调节能量稳态的重要途径。由于神经传递系统和miRNA似乎都对ELS敏感，本综述的目的是带来关于miRNA在控制进食行为中起核心作用的新见解，重点关注ELS的影响和神经传递系统的调节。
