基于首段尿液的 HPV 疫苗诱导抗体的无创评估
Non-invasive Assessment of Vaccine-Induced HPV Antibodies via First-Void Urine.
机构信息
Faculty of Medicine and Health Sciences, Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.
出版信息
Front Immunol. 2020 Aug 5;11:1657. doi: 10.3389/fimmu.2020.01657. eCollection 2020.
Abstract
The potential of first-void (FV) urine as a non-invasive method to monitor human papillomavirus (HPV) vaccination has been reported, mainly focusing on urine as a sample to assess HPV DNA. Besides HPV DNA, vaccine-induced HPV antibodies originating from cervicovaginal secretions were recently shown to be detectable in FV urine as well. This presents a novel opportunity for non-invasive sampling to monitor HPV antibody status in women participating in large epidemiological studies and HPV vaccine trials. The simultaneous assessment of both HPV infection and immunogenicity on a non-invasive, readily obtained sample is particularly attractive.
摘要
已有研究报道，首段尿（FV）可作为一种非侵入性方法来监测人乳头瘤病毒（HPV）疫苗接种，主要集中在利用尿液样本来评估 HPV DNA。除 HPV DNA 外，最近还发现来源于宫颈阴道分泌物的疫苗诱导 HPV 抗体也可在 FV 尿中检测到。这为在参与大型流行病学研究和 HPV 疫苗试验的女性中进行非侵入性采样监测 HPV 抗体状态提供了新的机会。同时在一个非侵入性、易于获得的样本上评估 HPV 感染和免疫原性具有特别的吸引力。
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