Division of Adolescent Medicine, Indiana University School of Medicine, Indianapolis, IN.
Epidemiology Department, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN.
Transplantation. 2021 Apr 1;105(4):736-742. doi: 10.1097/TP.0000000000003444.
Survivors of childhood cancer and other immunocompromised children are at high risk for the development of secondary human papillomavirus (HPV)-associated cancers. In this overview, the authors examine the epidemiology of vaccine efficacy, the natural history of HPV infections, and accelerated HPV-associated cancer development in these populations. The authors highlight the opportunities for preventive care and future research directives.
儿童癌症幸存者和其他免疫功能低下的儿童发生人乳头瘤病毒（HPV）相关癌症的风险较高。在这篇综述中，作者研究了疫苗疗效的流行病学、HPV 感染的自然史，以及这些人群中 HPV 相关癌症的加速发展。作者强调了预防保健和未来研究方向的机会。
