Teufel M, Kleeberg J, Flach A, Reifferscheid P, Niessen K H
Universitäts-Kinderklinik Mannheim.
Klin Padiatr. 1988 Jan-Feb;200(1):30-5. doi: 10.1055/s-2008-1033681.
26 children were investigated on an average 11.5 years after partial (n = 13) and total (n = 13) colonic resection. Total colectomy was followed by an increased frequency of gastrointestinal symptoms such as recurrent abdominal pain, flatulence, attacks of diarrhoea, frequent and pasty or liquid stools with strange smell. An increased salt or fluid intake was observed in one half of these patients. Their height and bone age was slightly but significantly reduced. Laboratory investigations revealed no significant deficiencies of electrolyts, vitamins or trace elements. However Renin (mean and 2s-range = 5.2; 2.7-6.8 ng/ml.h, normal values (NV) 1.3; 0.5-4.0 ng/ml.h, p less than 0.02), aldosterone (242.1; 168.4-357.8 pg/ml, NV 78.9; 39.4-168.4 pg/ml, *p less than 0.02), conjugated bile acids (11.3; 5.2-20.0 mumol/1, NV 4.2; 1.5-7.0 mumol/1, p less than 0.01) and serum urea concentration (32.5; 20.8-48.7 mg/dl, NV 14.6; 6.0-22.5 mg/dl, p less than 0.01) were significantly elevated. Three postprandial plasma levels of gastrin, VIP and neurotensin were within normal limits. In patients with partial large bowel resection all signs were less pronounced. According to our results a special diet in children years after colectomy seems not to be required.
对26名儿童进行了调查，这些儿童在接受部分结肠切除（n = 13）和全结肠切除（n = 13）后平均11.5年。全结肠切除术后，胃肠道症状的发生率增加，如反复腹痛、肠胃胀气、腹泻发作、频繁排出糊状或水样且有异味的粪便。这些患者中有一半观察到盐或液体摄入量增加。他们的身高和骨龄略有但显著降低。实验室检查未发现电解质、维生素或微量元素有明显缺乏。然而，肾素（平均值及2倍标准差范围 = 5.2；2.7 - 6.8 ng/ml·h，正常范围（NV）1.3；0.5 - 4.0 ng/ml·h，p < 0.02）、醛固酮（242.1；168.4 - 357.8 pg/ml，NV 78.9；39.4 - 168.4 pg/ml，*p < 0.02）、结合胆汁酸（11.3；5.2 - 20.0 μmol/L，NV 4.2；1.5 - 7.0 μmol/L，p < 0.01）和血清尿素浓度（32.5；20.8 - 48.7 mg/dl，NV 14.6；6.0 - 22.5 mg/dl，p < 0.01）显著升高。餐后血浆中胃泌素、血管活性肠肽和神经降压素的三个水平均在正常范围内。在接受部分大肠切除的患者中，所有症状都不那么明显。根据我们的结果，结肠切除术后数年的儿童似乎不需要特殊饮食。
