Teufel M, Niessen K H
Monatsschr Kinderheilkd. 1986 Feb;134(2):96-101.
Neurotensin is a 13-amino acid hormonal peptide, localized to specific areas in both the brain and gastrointestinal tract of many mammalian species. It has been described as causing a wide variety of central and peripheral actions. At present there is almost no information concerning the possible physiological and pathophysiological significance of this peptide especially in childhood. Therefore we investigated plasma concentrations of neurotensin-like immunoreactivity in 113 healthy and 103 children suffering from various gastrointestinal diseases. The fasting levels (48.7 +/- 17.4 pg/ml) were slightly lower (p less than 0.05) than our postprandial concentrations (72.9 +/- 28.1 pg/ml) 2-3 hours after breakfast. There was no age distribution. Significantly elevated levels were found in CF-patients (185.4 +/- 96.1 pg/ml; p less than 0.0001) and three children with active coeliac disease (252.3 pg/ml), whereas patients with Crohn's disease, ulcerative colitis and abdominal pain had normal values. Children after large bowel resection showed elevated plasma levels of neurotensin-like immunoreactivity (87.3 +/- 36.4 pg/ml), however, the differences were not significant.
神经降压素是一种由13个氨基酸组成的激素肽，存在于许多哺乳动物大脑和胃肠道的特定区域。它具有多种中枢和外周作用。目前，关于这种肽可能的生理和病理生理意义，尤其是在儿童期，几乎没有相关信息。因此，我们对113名健康儿童和103名患有各种胃肠道疾病的儿童的血浆神经降压素样免疫反应性浓度进行了研究。空腹水平（48.7±17.4 pg/ml）略低于早餐后2至3小时的餐后浓度（72.9±28.1 pg/ml）（p<0.05）。未发现年龄分布差异。囊性纤维化患者（185.4±96.1 pg/ml；p<0.0001）和3名活动性乳糜泻儿童（252.3 pg/ml）的水平显著升高，而克罗恩病、溃疡性结肠炎和腹痛患者的水平正常。大肠切除术后的儿童血浆神经降压素样免疫反应性水平升高（87.3±36.4 pg/ml），然而，差异不显著。
