Yilmaz Neslihan, Yazici Ayten, Özulu TÜrkmen Banu, Karalok Işık, Yavuz Şule
Department of Internal Medicine, Division of Rheumatology, Demiroğlu Bilim University Medial Faculty, Istanbul, Turkey.
Department of Internal Medicine, Division of Rheumatology, Kocaeli University Medial Faculty, Kocaeli, Turkey.
Arch Rheumatol. 2020 Jan 8;35(2):254-258. doi: 10.46497/ArchRheumatol.2020.7514. eCollection 2020 Jun.
This study aims to investigate the prevalence of inflammatory back pain (IBP) and sacroiliitis in a systemic lupus erythematosus (SLE) population as well as the association between IBP and the frequency of human leukocyte antigen B27 (HLA-B27).
The study included 281 SLE patients (16 males, 265 females; mean age 39.9±11.9 years; range, 20 to 69 years) and 100 healthy controls (HCs) (2 males, 98 females; mean age 41.2±10.1 years; range, 19 to 64 years). Participants were administered a five-item Assessment of SpondyloArthritis international Society-IBP questionnaire. Patients and controls with IBP underwent detailed clinical and laboratory examinations to detect sacroiliitis. Radiographic evaluations were performed by a blinded rheumatologist and radiologist. Interobserver reliability was assessed with Cohen's kappa test.
According to the questionnaire, IBP was present in 46 SLE patients (46/281; 16.3%) whereas none of the HC had IBP (p<0.001). In radiological assessment, 22 SLE patients (7.8%) had sacroiliitis detected by conventional X-ray and/or magnetic resonance imaging. Only one SLE patient with sacroiliitis had HLA-B27.
Our study showed that IBP is increased in SLE patients and IBP in SLE is not associated with HLA-B27.
本研究旨在调查系统性红斑狼疮（SLE）患者中炎性背痛（IBP）和骶髂关节炎的患病率，以及IBP与人类白细胞抗原B27（HLA - B27）频率之间的关联。
该研究纳入了281例SLE患者（16例男性，265例女性；平均年龄39.9±11.9岁；范围20至69岁）和100例健康对照者（HCs）（2例男性，98例女性；平均年龄41.2±10.1岁；范围19至64岁）。参与者接受了一项五项的国际脊柱关节炎协会-IBP问卷评估。患有IBP的患者和对照者接受了详细的临床和实验室检查以检测骶髂关节炎。由一位不知情的风湿病学家和放射科医生进行影像学评估。采用Cohen's kappa检验评估观察者间的可靠性。
根据问卷，46例SLE患者存在IBP（46/281；16.3%），而HCs中无一例有IBP（p<0.001）。在影像学评估中，22例SLE患者（7.8%）通过传统X线和/或磁共振成像检测出骶髂关节炎。仅有1例患有骶髂关节炎的SLE患者有HLA - B27。
我们的研究表明SLE患者中IBP增加，且SLE中的IBP与HLA - B27无关。
