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胃旁路术与袖状胃切除术治疗胃束带术失败的比较:一项采用倾向评分匹配分析的两中心研究。

Comparison of sleeve gastrectomy and Roux-en-Y gastric bypass after failure of gastric banding: a two-center study with a propensity score-matched analysis.

机构信息

Department of Digestive Surgery, Caen University Hospital, Avenue de la Côte de Nacre, 14033, Caen, France.

Department of Digestive, Esogastric and Bariatric Surgery, Bichat Claude Bernard University Hospital, 46 rue Henri Huchard, 75018, Paris, France.

出版信息

Surg Endosc. 2021 Jul;35(7):3513-3522. doi: 10.1007/s00464-020-07809-9. Epub 2020 Aug 26.

DOI:10.1007/s00464-020-07809-9
PMID:32851467
Abstract

BACKGROUND

Few studies on series comparing sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) after failure of gastric banding (GB) are available. The objective of this study was to compare the short- and medium-term outcomes of SG and RYGB after GB.

MATERIALS AND METHODS

Between January 2006 and December 2017, patients undergoing SG (n = 186) or RYGB (n = 107) for failure of primary GB were included in this two-center study. Propensity-score matching was performed based on preoperative factors with a 2:1 ratio. Primary endpoint was the weight loss at 2 years between the SG and RYGB groups. Secondary endpoints were overall mortality and morbidity, reoperation, correction of comorbidities and the rate of adverse events at 2 years follow-up.

RESULTS

In our propensity score matching analysis, operative time was significantly less in the SG group (95 min vs. 179 min; p < 0.001). Post-operative complications were lower in the SG group (9.5% vs. 35.4%; p = 0.003). At 2 years follow-up, the mean EWL was similar as same as comorbidities. There was a significant difference in favor of SG concerning the rate of adverse events at 2 years follow-up (p < 0.001).

CONCLUSION

Revision of GB by SG or RYGB is feasible, with a higher rate of early post-operative complications for RYGB. Weight loss at 2 years follow-up is similar; however, RYGB appears to result in a higher rate of adverse events than SG.

摘要

背景

关于胃旁路术(RYGB)和袖状胃切除术(SG)治疗胃束带术(GB)失败后短期和中期结果的比较研究较少。本研究旨在比较 GB 失败后行 SG 和 RYGB 的短期和中期结果。

材料与方法

本研究为单中心回顾性研究,纳入 2006 年 1 月至 2017 年 12 月期间因初次行 GB 失败而行 SG(n=186)或 RYGB(n=107)的患者。根据术前因素采用 2:1 的比例进行倾向评分匹配。主要终点为 SG 与 RYGB 两组患者在 2 年时的减重效果。次要终点为总死亡率和发病率、再次手术、合并症的矫正以及 2 年随访时不良事件的发生率。

结果

在倾向评分匹配分析中,SG 组的手术时间明显更短(95 分钟 vs. 179 分钟;p<0.001)。SG 组术后并发症发生率较低(9.5% vs. 35.4%;p=0.003)。在 2 年随访时,两组患者的平均 EWL 相似,但在不良事件发生率方面,SG 组明显更优(p<0.001)。

结论

GB 翻修为 SG 或 RYGB 是可行的,RYGB 的早期术后并发症发生率较高。2 年随访时的减重效果相似,但 RYGB 组的不良事件发生率似乎高于 SG 组。

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