Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Department of Neonatology, Wenling Maternal and Child Health Care Hospital, Wenling, Zhejiang Province, China.
Eur J Pediatr. 2021 Mar;180(3):791-797. doi: 10.1007/s00431-020-03787-1. Epub 2020 Aug 27.
The aim of this study is to explore the association between umbilical cord blood (UCB) vitamin A levels and late preterm infants morbidities. We conducted a prospective cohort study of 208 late-preterm infants(from 34 / to 36 / weeks gestational age) between January 1, 2014 and June 30, 2015. UCB specimens were collected shortly after birth, and vitamin A levels were determined by enzyme-linked immunosorbent assay. Prevalence of low UCB vitamin A level < 0.7 μmol/L was 37.5% in late preterm infants. In comparison to vaginal delivery, cesarean section was associated with UCB vitamin A level < 0.7 μmol/L (P < 0.001). Nevertheless, UCB vitamin A levels did not correlate with gestational age, birth weight, and gender. UCB vitamin A level < 0.7 μmol/L was not an independent risk factor for hospitalization, oxygen supplementation, hyperbilirubinemia, sepsis, and respiratory distress syndrome.Conclusions: Low umbilical cord blood vitamin A levels are common among late-preterm infants. Cesarean section delivery is associated with low umbilical cord blood vitamin A level. Low umbilical cord blood vitamin A levels at birth do not increase morbidity of late-preterm infants, including hyperbilirubinemia, sepsis, and respiratory distress syndrome. What is Known: • Late preterm infants have a higher morbidity and mortality rates when compared to term infants. • Low plasma vitamin A levels increase the risk of preterm infants' morbidity. What is New: • Late preterm infants commonly have low level of umbilical cord blood vitamin A. • Low umbilical cord blood vitamin A level at birth appears to be not associated with the morbidity of late-preterm infants. • Cesarean section is associated with low umbilical cord blood vitamin A level < 0.7 μmol/L compared with vaginal delivery.
本研究旨在探讨脐血（UCB）维生素 A 水平与晚期早产儿发病的关系。我们对 208 例（胎龄 34 至 36 周）晚期早产儿进行了前瞻性队列研究，这些婴儿均于 2014 年 1 月 1 日至 2015 年 6 月 30 日期间出生。婴儿出生后不久采集 UCB 标本，采用酶联免疫吸附试验测定维生素 A 水平。晚期早产儿中 UCB 维生素 A 水平<0.7 μmol/L 的发生率为 37.5%。与阴道分娩相比，剖宫产与 UCB 维生素 A 水平<0.7 μmol/L 相关（P<0.001）。然而，UCB 维生素 A 水平与胎龄、出生体重和性别无关。UCB 维生素 A 水平<0.7 μmol/L 不是住院、吸氧、高胆红素血症、败血症和呼吸窘迫综合征的独立危险因素。结论：晚期早产儿 UCB 维生素 A 水平低较为常见。剖宫产与 UCB 维生素 A 水平低有关。出生时 UCB 维生素 A 水平低不会增加晚期早产儿的发病风险，包括高胆红素血症、败血症和呼吸窘迫综合征。已知情况：与足月儿相比，晚期早产儿的发病率和死亡率更高。低血浆维生素 A 水平增加早产儿发病的风险。新情况：晚期早产儿 UCB 维生素 A 水平普遍较低。出生时 UCB 维生素 A 水平低似乎与晚期早产儿的发病无关。与阴道分娩相比，剖宫产与 UCB 维生素 A 水平<0.7 μmol/L 有关。
