Kastamonu University Faculty of Medicine, Department of Ophthalmology, Kastamonu, Turkey.
Katip Çelebi University Atatürk Educating and Research Hospital, Department of Ophthalmology, İzmir, Turkey.
Photodiagnosis Photodyn Ther. 2021 Dec;36:102482. doi: 10.1016/j.pdpdt.2021.102482. Epub 2021 Aug 11.
To detect the changes that can be determined with optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in young and short-term smokers.
In this cross-sectional, observational, and comparative study, 45 "healthy" smokers and 45 healthy non-smoker control participants were included. Those with a smoking history between 1 year to 5 years and an average of 10-30 cigarettes per day were included in the study. OCT and OCTA measurements were made at least 60 min after smoking and at least 8 h after caffeine-containing beverages in order to end the effect of nicotine on systemic and retinal blood flow in the smoking group.
The mean smoking period was 2.2 ± 0.13 years. Mean macular thickness(MMT), retinal nerve fiber layer(RNFL), and choroidal thickness(Cht) were significantly lower in the smoker group, while ganglion cell-inner plexiform layer(GC-IPL) thickness was higher. Vessel density(VD) values were similar between groups, while perfusion density(PD) values were significantly higher in the smoker group. There were significant correlations between MMT and outer VD, outer PD, foveal avascular zone(FAZ) perimeter and circularity index. FAZ area and central VD and PD were inversely correlated. Also, FAZ circularity index and subfoveal, nasal, and temporal ChTs were positively correlated.
Despite the short-term smoking, ischemic effects were observed in retinochoroidal and vascular structures.
检测光学相干断层扫描（OCT）和光学相干断层扫描血管造影（OCTA）在年轻和短期吸烟者中可检测到的变化。
在这项横断面、观察性和对照研究中，纳入了 45 名“健康”吸烟者和 45 名健康非吸烟者对照者。将吸烟史在 1 年至 5 年之间、平均每天吸烟 10-30 支的患者纳入研究。为了结束尼古丁对吸烟组全身和视网膜血流的影响，在吸烟后至少 60 分钟和含咖啡因饮料后至少 8 小时进行 OCT 和 OCTA 测量。
平均吸烟时间为 2.2±0.13 年。吸烟者组的黄斑厚度(MMT)、视网膜神经纤维层(RNFL)和脉络膜厚度(Cht)明显较低，而神经节细胞内丛状层(GC-IPL)厚度较高。血管密度(VD)值在两组之间相似，而灌注密度(PD)值在吸烟者组中明显较高。MMT 与外 VD、外 PD、中心无血管区(FAZ)周长和圆度指数之间存在显著相关性。FAZ 面积与中心 VD 和 PD 呈负相关。此外，FAZ 圆度指数与中心凹下、鼻侧和颞侧 ChTs 呈正相关。
尽管吸烟时间较短，但在视网膜脉络膜和血管结构中观察到缺血效应。
