Zuo Long, Zhou Yang, Wang Shuangkun, Wang Biao, Gu Hua, Chen Jingnan
Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Int Urol Nephrol. 2021 Jan;53(1):27-33. doi: 10.1007/s11255-020-02614-8. Epub 2020 Aug 26.
To investigate whether patients with overactive bladder syndrome (OAB) have brain volume changes using voxel-based morphometry (VBM) and correlations with clinical tests.
With institutional review board approval and after obtaining written informed consent, structural magnetic resonance imaging data were prospectively acquired in 28 patients and 28 control subjects. OAB symptoms were assessed using the OAB symptom score (OABSS) scale. The gray matter volume (GMV) of each voxel was compared between the two groups while controlling for the effects of age, sex, and education level. Correlation analysis was performed to identify correlations between abnormal GMV regions and OABSS scores in patients. Multiple comparisons were corrected using a false discovery rate (FDR) method.
Patients with OAB exhibited a GMV reduction in the right cerebellum, bilateral hippocampus, left insula, right superior temporal gyrus, left anterior cingulate gyrus, bilateral caudate nucleus and right middle frontal gyrus. Furthermore, there was a significant negative correlation between the local GMV of the right cerebellar hemisphere and OABSS score.
Patients with OAB have abnormal GMV in brain regions localized within the brain-bladder control network. It deepens our understanding of the structural changes in the brain area of the network. The patterns of structural reorganization in patients with OAB may provide useful information in the neuropathological mechanisms of the OAB.
采用基于体素的形态学测量（VBM）方法研究膀胱过度活动症（OAB）患者是否存在脑容量变化，并探讨其与临床检查结果的相关性。
在获得机构审查委员会批准并取得书面知情同意后，前瞻性地采集了28例患者和28例对照者的结构磁共振成像数据。使用OAB症状评分（OABSS）量表评估OAB症状。在控制年龄、性别和教育水平影响的同时，比较两组之间每个体素的灰质体积（GMV）。进行相关性分析以确定患者异常GMV区域与OABSS评分之间的相关性。采用错误发现率（FDR）方法校正多重比较。
OAB患者右侧小脑、双侧海马、左侧岛叶、右侧颞上回、左侧前扣带回、双侧尾状核和右侧额中回的GMV减少。此外，右侧小脑半球局部GMV与OABSS评分之间存在显著负相关。
OAB患者在脑-膀胱控制网络内的脑区存在GMV异常。这加深了我们对该网络脑区结构变化的理解。OAB患者的结构重组模式可能为OAB的神经病理机制提供有用信息。
