College of Chemistry, Jilin University, Changchun, Jilin, 130012, P. R. China.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, P. R. China.
Small. 2020 Oct;16(39):e2003707. doi: 10.1002/smll.202003707. Epub 2020 Aug 26.
Nanomaterial-based pancreatic cancer treatment has received widespread attention and rapid development in the past few years. The major challenges include the poor combination of diagnosis and therapy, the difficulty in targeting therapy from the root and the unsatisfactory antitumor efficiency, which is accompanied by a great risk of relapse and metastasis. In this work, a positively charged lipid bilayer membrane is coated on reduced graphene oxide@gold nanostar (rGO@AuNS) for photoacoustic/photothermal dual-modal imaging-guided gene/photothermal synergistic therapy of pancreatic cancer. In addition, the cross-linking of folic acid on the surface of rGO@AuNS-lipid can specifically bind after recognizing folic acid receptors on the surface of cancer cells, and greatly improve the targeting ability of the nanomaterial and the performance of imaging diagnosis by receptor-mediated endocytosis. Moreover, the photothermal and gene (targeting G12V mutant K-Ras gene) synergistic therapy shows outstanding anticancer efficacy for pancreatic cancer tumor bearing mice, and it is noteworthy that the treatment groups have anti-liver metastasis of pancreatic cancer.
基于纳米材料的胰腺癌治疗在过去几年中受到了广泛关注和快速发展。主要挑战包括诊断和治疗的结合不佳、从根本上靶向治疗的困难以及抗肿瘤效率不理想，同时伴随着复发和转移的巨大风险。在这项工作中，在还原氧化石墨烯@gold 纳米星（rGO@AuNS）上包覆带正电荷的脂质双层膜，用于光声/光热双模态成像引导的胰腺癌基因/光热协同治疗。此外，rGO@AuNS-脂质表面上的叶酸交联在识别癌细胞表面的叶酸受体后可以特异性结合，通过受体介导的内吞作用极大地提高了纳米材料的靶向能力和成像诊断性能。此外，光热和基因（靶向 G12V 突变 K-Ras 基因）协同治疗对荷胰腺癌肿瘤的小鼠表现出优异的抗癌疗效，值得注意的是，治疗组具有抗胰腺癌肝转移的作用。
