从红树林内生真菌 sp. GXNU-A9 中分离得到的一种新的漆酚衍生物。

A new depsidone derivative from mangrove endophytic fungus sp. GXNU-A9.

机构信息

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, P.R. China.

出版信息

Nat Prod Res. 2022 Apr;36(7):1878-1882. doi: 10.1080/14786419.2020.1809400. Epub 2020 Aug 27.

DOI:10.1080/14786419.2020.1809400

PMID:32851874

Abstract

A new tetracyclic depsidone derivative, guanxidone A (), together with three known metabolites -, was isolated from the mangrove endophytic fungus sp. GXNU-A9. The structure of compound was established by HR-ESI-MS, 1 D and 2 D NMR data, as well as by comparison with literature data. Compounds - were evaluated for their anti-inflammatory effects on the production of the nitric oxide (NO), and compound significantly reduced the production of NO in lipopolysaccharide (LPS)-stimulated cells with IC value of 8.22 M.

摘要

从红树林内生真菌 sp. GXNU-A9 中分离得到了一个新的四环去甲倍半萜衍生物 Guanxidone A (), 以及三个已知代谢物 -, 。化合物的结构通过高分辨电喷雾质谱 (HR-ESI-MS) 、1D 和 2D NMR 数据以及与文献数据的比较确定。评估了化合物 - 对一氧化氮 (NO) 产生的抗炎作用，化合物显著降低了脂多糖 (LPS) 刺激细胞中 NO 的产生，IC 值为 8.22 M。