从红树林内生真菌 Aspergillus sp. GXNU-4QQY1a 中分离得到的新型环肽及其杀虫活性。

Isolation and insecticidal activities of new cyclic peptides from mangrove endophytic fungus Aspergillus sp. GXNU-4QQY1a.

机构信息

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.

Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology, Hechi University, Hechi 546300, China.

出版信息

Fitoterapia. 2023 Dec;171:105693. doi: 10.1016/j.fitote.2023.105693. Epub 2023 Sep 26.

DOI:10.1016/j.fitote.2023.105693

PMID:37769999

Abstract

An investigation on bioactive metabolites from the mangrove endophytic fungus Aspergillus sp. GXNU-4QQY1a led to the isolation of two undescribed cyclic peptides, guaspertide A (1) and guaspertide B (2), together with six known compounds, 3-8. These structures and the new compounds' absolute configuration were determined by mass spectrometry analysis, nuclear magnetic resonance spectrum, electronic circular dichroism, and single-crystal X-ray diffraction. Insecticidal assays were carried out with compounds 1-8, and the results showed that compounds 1-3 and 8 exhibited good insecticidal activity against citrus psyllids.

摘要

从红树林内生真菌 Aspergillus sp. GXNU-4QQY1a 中进行生物活性代谢产物的研究，分离得到两个未被描述的环肽，瓜斯肽 A（1）和瓜斯肽 B（2），以及六个已知化合物，3-8。这些结构和新化合物的绝对构型通过质谱分析、核磁共振谱、电子圆二色性和单晶 X 射线衍射来确定。对化合物 1-8 进行了杀虫活性测试，结果表明，化合物 1-3 和 8 对柑橘木虱具有良好的杀虫活性。