从红树林内生真菌 sp. GXNU-MA1 中分离得到的一种新倍半萜。

A new sesquiterpene from mangrove endophytic fungus sp. GXNU-MA1.

机构信息

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, P. R. China.

出版信息

Nat Prod Res. 2022 Apr;36(7):1857-1863. doi: 10.1080/14786419.2020.1824225. Epub 2020 Sep 23.

DOI:10.1080/14786419.2020.1824225

PMID:32962429

Abstract

A new sesquiterpene, gxsespene A (1), and four known sesquiterpene derivatives were isolated from the mangrove endophytic fungus sp. GXNU-MA1. Their structures were elucidated based on high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS) datum, extensive nuclear magnetic resonance (NMR) spectroscopic analysis, and comparison with literature data. The structure of was further confirmed by single-crystal X-ray diffraction analysis, and the absolute configuration of was established. Compounds were evaluated for their anti-inflammatory activities against the nitric oxide (NO) production, and compounds showed moderate inhibitory activities with IC values ranging from 16.15 to 27.08 M.

摘要

从红树林内生真菌 sp. GXNU-MA1 中分离得到一个新的倍半萜，gxsespene A（1）和四个已知的倍半萜衍生物。根据高分辨电喷雾电离质谱（HR-ESI-MS）数据、广泛的核磁共振（NMR）光谱分析以及与文献数据的比较，确定了它们的结构。通过单晶 X 射线衍射分析进一步确定了的结构，并确定了的绝对构型。对化合物进行了抗炎活性评价，针对一氧化氮（NO）的产生，化合物表现出适度的抑制活性，IC 值范围为 16.15 至 27.08μM。