State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, P. R. China.
Nat Prod Res. 2022 Apr;36(7):1857-1863. doi: 10.1080/14786419.2020.1824225. Epub 2020 Sep 23.
A new sesquiterpene, gxsespene A (1), and four known sesquiterpene derivatives were isolated from the mangrove endophytic fungus sp. GXNU-MA1. Their structures were elucidated based on high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS) datum, extensive nuclear magnetic resonance (NMR) spectroscopic analysis, and comparison with literature data. The structure of was further confirmed by single-crystal X-ray diffraction analysis, and the absolute configuration of was established. Compounds were evaluated for their anti-inflammatory activities against the nitric oxide (NO) production, and compounds showed moderate inhibitory activities with IC values ranging from 16.15 to 27.08 M.
从红树林内生真菌 sp. GXNU-MA1 中分离得到一个新的倍半萜，gxsespene A（1）和四个已知的倍半萜衍生物。根据高分辨电喷雾电离质谱（HR-ESI-MS）数据、广泛的核磁共振（NMR）光谱分析以及与文献数据的比较，确定了它们的结构。通过单晶 X 射线衍射分析进一步确定了的结构，并确定了的绝对构型。对化合物进行了抗炎活性评价，针对一氧化氮（NO）的产生，化合物表现出适度的抑制活性，IC 值范围为 16.15 至 27.08μM。
