School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Department of Pharmaceutical Sciences, School of Bioscience and Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh 226025, India.
Curr Pharm Des. 2020;26(42):5468-5487. doi: 10.2174/1381612826666200826164322.
Flavonoids are secondary metabolites that are widely distributed in plants. These phenolic compounds are classified into various subgroups based on their structures: flavones, flavonols, isoflavones, flavanones, and anthocyanins. They are known to perform various pharmacological actions like antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic and antiallergic, etc. Diabetes is a chronic progressive metabolic disorder that affects several biochemical pathways and leads to secondary complications such as neuropathy, retinopathy, nephropathy, and cardiomyopathy. Among them, the management of diabetic neuropathy is one of the major challenges for physicians as well as the pharmaceutical industries. Naturally occurring flavonoids are extensively used for the treatment of diabetes and its related complications due to their antioxidant properties. Moreover, flavonoids inhibit various pathways that are involved in the progression of diabetic neuropathy like the reduction of oxidative stress, decrease in glycogenolysis, increase glucose utilization, decrease in the formation of advanced glycation end products, and inhibition of the α-glucosidase enzyme. This review entails current updates on the therapeutic perspectives of flavonoids in the treatment of neuropathic pain. This manuscript explains the pathological aspects of neuropathic pain, the chemistry of flavonoids, and their application in amelioration of neuropathic pain through preclinical studies either alone or in combination with other therapeutic agents.
类黄酮是广泛存在于植物中的次生代谢产物。这些酚类化合物根据其结构分为不同的亚组：黄酮类、黄酮醇类、异黄酮类、黄烷酮类和花青素类。它们具有多种药理作用，如抗氧化、抗炎、抗癌、抗菌、抗糖尿病和抗过敏等。糖尿病是一种慢性进行性代谢紊乱，影响多种生化途径，并导致神经病变、视网膜病变、肾病和心肌病等继发性并发症。其中，糖尿病神经病变的治疗是医生和制药行业面临的主要挑战之一。由于具有抗氧化特性，天然存在的类黄酮被广泛用于治疗糖尿病及其相关并发症。此外，类黄酮抑制参与糖尿病神经病变进展的各种途径，如降低氧化应激、减少糖原分解、增加葡萄糖利用、减少晚期糖基化终产物的形成以及抑制α-葡萄糖苷酶。这篇综述涉及类黄酮在治疗神经性疼痛方面的治疗前景的最新进展。本文通过临床前研究，解释了神经性疼痛的病理方面、类黄酮的化学性质以及它们通过单独或与其他治疗剂联合应用来改善神经性疼痛的应用。
