Bayerl Christiane
Klinik für Dermatologie und Allergologie, Hauttumorzentrum Wiesbaden, Helios Dr. Horst Schmidt Kliniken, Ludwig-Erhard-Str. 100, 65199, Wiesbaden, Deutschland.
Hautarzt. 2020 Oct;71(10):786-790. doi: 10.1007/s00105-020-04674-4.
Topical hormonal treatment allows anti-aging of the skin when used during and after the menopause without an increase in the blood level of hormones. Natural hormones are only prescribed by medical doctors. In controlled clinical studies versus placebo and application for months, an increase in skin quality parameters, reduction of dryness, increase of glycosaminoglycanes, increase in elastic fibers und increase of collagen precursers and collagen fibers on the mRNA and protein level could be shown, the latter proven by biopsies. Skin with dramatic sun-damage does not respond to this treatment option. Patients with melasma or seborrhoe should not be treated with hormonal topical preparations. Compared to the natural hormones, phytotherapeutics do not bind to hormone receptors in relevant levels. Growth hormones should not be used in anti-aging treatment due to a potential carcinogenic effect.
局部激素治疗可在绝经期间及之后使用，实现皮肤抗老化，且不会使血液中激素水平升高。天然激素仅由医生开具处方。在与安慰剂对比的对照临床研究中，经过数月的应用，可显示皮肤质量参数增加、干燥减轻、糖胺聚糖增加、弹性纤维增加以及在mRNA和蛋白质水平上胶原前体和胶原纤维增加，后者经活检证实。有严重晒伤的皮肤对这种治疗方案无反应。患有黄褐斑或脂溢性皮炎的患者不应使用激素局部制剂。与天然激素相比，植物疗法在相关水平上不会与激素受体结合。由于存在潜在致癌作用，生长激素不应在抗老化治疗中使用。
