Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.
State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, People's Republic of China.
J Agric Food Chem. 2020 Sep 16;68(37):9827-9838. doi: 10.1021/acs.jafc.0c04560. Epub 2020 Sep 7.
-Sativenes are a small group of sesquiterpenoids with a unique bicyclo[3.2.1]octane core carbon skeleton, which implies the unusual biosynthetic pathway. Up to date, there are 40 -sativene analogues with diverse post-modifications isolated from different fungi. Interestingly, some -sativene analogues display strong phytotoxic effects, whereas others possess plant-growth-promoting biological activities. The possible mechanism of actions about phytotoxic or growth-promoting activities are partly elucidated, but structure-activity relationships are still not clear. This review provides a comprehensive overview on the structures, H nuclear magnetic resonance features, bioactivities, and biosynthesis of -sativene sesquiterpenoids from 1956 to 2020.
萨提烯是一组具有独特双环[3.2.1]辛烷核心碳骨架的倍半萜烯，这暗示了其不寻常的生物合成途径。迄今为止，已经从不同真菌中分离出 40 种具有不同后修饰的萨提烯类似物。有趣的是，一些萨提烯类似物具有很强的植物毒性作用，而另一些则具有促进植物生长的生物活性。关于植物毒性或生长促进活性的可能作用机制部分已经阐明，但结构-活性关系仍不清楚。本文综述了 1956 年至 2020 年期间从真菌中分离得到的萨提烯倍半萜的结构、1H 核磁共振特征、生物活性和生物合成。
