Naturally Occurring -Sativene Sesquiterpenoid: Chemistry and Biology.

-Sativenes are a small group of sesquiterpenoids with a unique bicyclo[3.2.1]octane core carbon skeleton, which implies the unusual biosynthetic pathway. Up to date, there are 40 -sativene analogues with diverse post-modifications isolated from different fungi. Interestingly, some -sativene analogues display strong phytotoxic effects, whereas others possess plant-growth-promoting biological activities. The possible mechanism of actions about phytotoxic or growth-promoting activities are partly elucidated, but structure-activity relationships are still not clear. This review provides a comprehensive overview on the structures, H nuclear magnetic resonance features, bioactivities, and biosynthesis of -sativene sesquiterpenoids from 1956 to 2020.