Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.
National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, People's Republic of China.
J Nat Prod. 2020 May 22;83(5):1488-1494. doi: 10.1021/acs.jnatprod.9b01148. Epub 2020 Apr 17.
A series of -sativene sesquiterpenoids (-) including two new natural products ( and ), four new analogues (-), and six known analogues, helminthosporic acid (), drechslerine A (), drechslerine B (), helminthosporol (), helminthosporal acid (), and isosativenediol (), were purified from the endophytic fungus isolated from a desert plant, . The stereochemistry of helminthosporic acid () was established for the first time by X-ray diffraction, and the structures including relative and absolute configurations of these new compounds were determined by NMR and CD spectra together with biosynthetic considerations. Compounds - are the first -sativene sesquiterpenoids possessing a glucose group on C-15, C-15, and C-14, respectively. Compounds , , , and displayed strong phytotoxic effects on corn leaves by producing visible lesions, and helminthosporic acid () was shown to promote division of leaves and roots of with a dose-dependent relationship.
从一种沙漠植物内生真菌 中分离得到的一系列 -沙蚕烯倍半萜类化合物（-），包括两个新的天然产物（和）、四个新的类似物（-）以及六个已知的类似物，包括海利生酸（）、旋齿鲨烯 A（）、旋齿鲨烯 B（）、海利生醇（）、海利生酸（）和异沙蚕二烯二醇（）。通过 X 射线衍射首次确定了海利生酸（）的立体化学结构，通过 NMR 和 CD 光谱以及生物合成考虑确定了这些新化合物的结构，包括相对和绝对构型。化合物-是第一个在 C-15、C-15 和 C-14 上具有葡萄糖基团的 -沙蚕烯倍半萜类化合物。化合物 、、、和 对玉米叶片表现出强烈的植物毒性，产生可见的损伤，海利生酸（）表现出促进 的叶片和根部分裂的作用，且与剂量呈依赖性关系。
