Fan Xin, Torres-Luna Cesar, Azadi Marjan, Domszy Roman, Hu Naiping, Yang Arthur, David Allan E
Department of Chemical Engineering, Auburn University, Auburn, AL, United States.
Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, MD, United States.
Acta Biomater. 2020 Oct 1;115:60-74. doi: 10.1016/j.actbio.2020.08.025. Epub 2020 Aug 25.
Soft contact lenses have generated growing interest in ocular drug delivery due to their potential to enhance drug bioavailability in ocular tissues. Commercially available soft contact lenses offer several advantages for ocular drug delivery as they are manufactured on a large scale, which guarantees the availability of a consistent and reproducible product, and their favorable safety profile is well-established through broad clinical use. Here we review the rationale for using commercially available soft contact lenses for ocular drug delivery; summarize the evolution of the materials used in contact lens fabrication; and explore various methods used to improve the drug release characteristics and its tissue penetration. While significant progress has been made, several issues still require further attention for the commercial launch of a viable drug-eluting contact lens product, including control of initial burst release, shelf-life stability, and drug loss during processing or storage.
软性隐形眼镜因其具有提高眼部组织中药物生物利用度的潜力，在眼部药物递送方面引起了越来越多的关注。市售的软性隐形眼镜为眼部药物递送提供了几个优势，因为它们是大规模生产的，这保证了产品的一致性和可重复性，并且通过广泛的临床应用，其良好的安全性已得到充分确立。在此，我们回顾了使用市售软性隐形眼镜进行眼部药物递送的基本原理；总结了隐形眼镜制造中所用材料的演变；并探索了用于改善药物释放特性及其组织渗透的各种方法。虽然已经取得了重大进展，但在可行的药物洗脱隐形眼镜产品商业化推出方面，仍有几个问题需要进一步关注，包括初始突释的控制、保质期稳定性以及加工或储存过程中的药物损失。
