Ocular Therapeutics Research Group (OTRG), Pharmaceutical & Molecular Biotechnology Research Centre (PMBRC), Waterford Institute of Technology, Waterford City, County Waterford X91 K0EK, Ireland.
Research and Development Department, Bausch + Lomb Ireland Ltd., Waterford City, County Waterford X91 V383, Ireland.
Cont Lens Anterior Eye. 2021 Dec;44(6):101487. doi: 10.1016/j.clae.2021.101487. Epub 2021 Aug 3.
Therapeutic contact lenses for ocular drug delivery have received considerable interest as they can potentially enhance ocular bioavailability, increase patient compliance, and reduce side effects. Along with the successful in vitro and in vivo studies on sustained drug delivery through contact lenses, lens critical properties such as water content, optical transparency and modulus have also been investigated. Aside from issues such as drug stability or burst release, the potential for the commercialization of pharmaceutical-loaded lenses can be limited by the alteration of lens physical and chemical properties upon the incorporation of therapeutic or non-therapeutic components. This review outlines advances in the use of pharmaceutical-loaded contact lenses and their relevant characterization methodologies as a potential ocular drug delivery system from 2010 to 2020, while summarizing current gaps and challenges in this field. A key reference point for this review is the relevant ISO standards on contact lenses, relating to the associated characterization methodologies. The content of this review is categorized based on the chemical, physical and mechanical properties of the loaded lens with the shortcomings of such analytical technologies examined.
治疗性接触镜在眼部药物传递方面受到了相当大的关注，因为它们有可能提高眼部生物利用度、增加患者依从性并降低副作用。随着通过接触镜进行持续药物传递的体外和体内研究的成功，水含量、光学透明度和模量等镜片关键特性也得到了研究。除了药物稳定性或爆发释放等问题外，由于治疗或非治疗成分的掺入会改变镜片的物理和化学性质，因此载药镜片的商业化潜力可能会受到限制。本文综述了 2010 年至 2020 年期间，载药接触镜及其相关特征化方法在作为潜在眼部药物传递系统方面的应用进展，同时总结了该领域目前存在的差距和挑战。本文的一个关键参考点是与相关特征化方法有关的接触镜相关 ISO 标准。本文综述的内容是根据载药镜片的化学、物理和机械性能进行分类的，并对这些分析技术的缺点进行了检查。
