Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland.
Free Radic Res. 2020 Jul;54(7):556-565. doi: 10.1080/10715762.2020.1815721. Epub 2020 Sep 10.
This study aimed to develop a procedure for preparing a modified silica-naringin hybrid system. To accomplish, the properties of the obtained material were characterized by FT-IR analysis, UV-Vis spectrophotometry, thermogravimetry, scanning electron microscopy (SEM), and zeta potential. 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was used to characterize and evaluate the antioxidant activity. The naringin release profile at pH = 1.2 and 7.2 were determined. FT-IR studies confirmed the interaction between the naringin and present carrier. The release study indicated that a release an approximately 20% and 50% of the release occurred in the first 30 min in pH = 1.2 and 7.2, respectively. The thermogravimetry and UV-Vis spectrophotometry analysis allowed us to determine the amount of naringin in the studied hybrid material at the level of several percent. The proposed hybrid material shows good stability, as evidenced by the zeta potential of about +30 and -30 mV in an acidic and alkaline environment, respectively. Antioxidant properties are comparable to those of pure naringin. The results suggest that the obtained hybrid material is a promising product with antioxidant properties.
本研究旨在开发一种制备改性硅胶-柚皮苷混合系统的方法。为了实现这一目标，通过傅里叶变换红外（FT-IR）分析、紫外可见分光光度法、热重分析、扫描电子显微镜（SEM）和动电位法对所得到的材料的性质进行了表征。采用 2,2-二苯基-1-苦基肼（DPPH）法对其抗氧化活性进行了表征和评价。在 pH = 1.2 和 7.2 时测定了柚皮苷的释放曲线。FT-IR 研究证实了柚皮苷与载体之间的相互作用。释放研究表明，在 pH = 1.2 和 7.2 时，分别在最初的 30 分钟内释放了约 20%和 50%的柚皮苷。热重分析和紫外可见分光光度分析允许我们在研究的混合材料中确定柚皮苷的含量达到百分之几的水平。所提出的混合材料表现出良好的稳定性，动电位分别约为+30 和-30 mV，分别在酸性和碱性环境中。抗氧化性能与纯柚皮苷相当。研究结果表明，所得到的混合材料是一种具有抗氧化性能的有前途的产品。
