Key Laboratory of Food Nutrition and Safety, Ministry of Education, School of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
Biomolecules. 2018 Jun 19;8(2):41. doi: 10.3390/biom8020041.
Pinocembrin is a natural flavonoid compound which is capable of antioxidant, antibacterial, anti-inflammatory, and antineoplastic activities. The present study aimed to enhance the solubility and antioxidant activities of pinocembrin by complex formation with lecithin. The physicochemical characteristics of pinocembrin⁻lecithin complex were analyzed by ultraviolet (UV), fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and solubility assay, and the antioxidant activities of pinocembrin⁻lecithin complex were evaluated via radical scavenging capacities for 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS), hydroxyl, and superoxide-anion. The results indicated that pinocembrin complex with lecithin could significantly improve the solubility of pinocembrin in water and -octane, the pinocembrin⁻lecithin complex displayed no characteristic endothermic peak and the appearance of amorphous state, compared to the pinocembrin, and no new covalent bond was produced in the pinocembrin and lecithin compound. It was demonstrated that the antioxidant activities of pinocembrin were obviously enhanced by the complex with lecithin, and the scavenging capacities for hydroxyl radical, DPPH, superoxide-anion radical, and ABTS radical of pinocembrin⁻lecithin complex were 82.44 ± 2.21%, 40.07 ± 1.32%, 59.15 ± 0.86%, and 24.73 ± 1.04% at 1.0 mg/mL, respectively. It suggested that the pinocembrin⁻lecithin complex had a great potential application prospect in the healthcare industry and in clinical practice.
乔松素是一种天然黄酮类化合物，具有抗氧化、抗菌、抗炎和抗肿瘤活性。本研究旨在通过与卵磷脂形成复合物来提高乔松素的溶解度和抗氧化活性。通过紫外（UV）、傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、差示扫描量热法（DSC）和溶解度测定分析乔松素-卵磷脂复合物的理化特性，并通过 2,2'-二苯基-1-苦基肼（DPPH）、2,2'-联氮-双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）、羟基和超氧阴离子自由基清除能力评价乔松素-卵磷脂复合物的抗氧化活性。结果表明，乔松素与卵磷脂形成复合物可显著提高乔松素在水中和正辛烷中的溶解度，与乔松素相比，乔松素-卵磷脂复合物没有特征性的吸热峰和无定形状态的出现，并且在乔松素和卵磷脂化合物中没有产生新的共价键。结果表明，乔松素与卵磷脂形成复合物可明显增强其抗氧化活性，乔松素-卵磷脂复合物对羟基自由基、DPPH、超氧阴离子自由基和 ABTS 自由基的清除能力分别为 82.44±2.21%、40.07±1.32%、59.15±0.86%和 24.73±1.04%，浓度为 1.0mg/mL。这表明乔松素-卵磷脂复合物在保健品行业和临床实践中有很大的潜在应用前景。
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