Ikuta Kunihiro, Sakai Tomohisa, Koike Hiroshi, Okada Tohru, Imagama Shiro, Nishida Yoshihiro
Department of Orthopaedic Surgery, Nagoya University Graduate School and School of Medicine, 65 Tsurumai, Showa, Nagoya, 466-8550, Japan.
Medical Genomics Center, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya, 466-8550, Japan.
World J Surg Oncol. 2020 Aug 27;18(1):227. doi: 10.1186/s12957-020-02009-0.
Myxoid liposarcoma is well known to have an unusual proclivity for extrapulmonary metastasis. However, cardiac metastasis of myxoid liposarcoma is very rare, even in patients with advanced disease.
A 40-year-old man was diagnosed with myxoid liposarcoma of the right thigh and treated with wide resection. Two years after the surgery, a low-density area in the left ventricle was found on follow-up chest computed tomography, and was suspected of being metastatic disease. He underwent surgical treatment, and the lesion was pathologically confirmed as metastasis of myxoid liposarcoma. Fifteen months later, he complained of slight dyspnea and developed metastatic disease in the right atrium. He was treated with surgical excision, followed by radiotherapy. Although there was no recurrence in the heart since the second cardiac metastasectomy, multiple metastases occurred in the abdominal cavity, lungs, and muscles. He finally died of the disease 2 years after the second cardiac metastasectomy.
We experienced a case of primary myxoid liposarcoma in the thigh, accompanied by ectopic and metachronous cardiac metastases. Although this condition is rare, we should follow-up patients with myxoid liposarcoma, considering the possibility of cardiac metastasis.
黏液样脂肪肉瘤以具有肺外转移的异常倾向而闻名。然而，黏液样脂肪肉瘤的心脏转移非常罕见，即使在晚期疾病患者中也是如此。
一名40岁男性被诊断为右大腿黏液样脂肪肉瘤，并接受了广泛切除治疗。手术后两年，随访胸部计算机断层扫描发现左心室有一个低密度区，怀疑是转移性疾病。他接受了手术治疗，病变经病理证实为黏液样脂肪肉瘤转移。15个月后，他主诉轻微呼吸困难，右心房出现转移性疾病。他接受了手术切除，随后进行了放疗。尽管自第二次心脏转移瘤切除术后心脏未复发，但腹腔、肺和肌肉出现了多处转移。他最终在第二次心脏转移瘤切除术后2年死于该疾病。
我们遇到了一例大腿原发性黏液样脂肪肉瘤，伴有异位和异时性心脏转移。尽管这种情况很少见，但考虑到心脏转移的可能性，我们应该对黏液样脂肪肉瘤患者进行随访。
