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黏液样脂肪肉瘤：在一家机构接受治疗的148例患者的预后因素和转移模式

Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution.

作者信息

Muratori Francesco, Bettini Leonardo, Frenos Filippo, Mondanelli Nicola, Greto Daniela, Livi Lorenzo, Franchi Alessandro, Roselli Giuliana, Scorianz Maurizio, Capanna Rodolfo, Campanacci Domenico

机构信息

Divisione di Ortopedia Oncologica e Ricostruttiva Ospedale, Azienda Universitaria Ospedaliera Careggi Firenze, Firenze, Italy.

Dipartimento di Radioterapia Azienda Ospedaliera Universitaria Careggi, Firenze, Italy.

出版信息

Int J Surg Oncol. 2018 May 16;2018:8928706. doi: 10.1155/2018/8928706. eCollection 2018.

DOI:10.1155/2018/8928706
PMID:29977616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6011058/
Abstract

OBJECTIVES

The authors reported a retrospective study on myxoid liposarcomas (MLs), evaluating factors that may influence overall survival (OS), local recurrence-free survival (LRFS), metastasis-free survival (MFS), and analyzing the metastatic pattern.

METHODS

148 MLs were analyzed. The sites of metastases were investigated.

RESULTS

Margins ( = 0.002), grading ( = 0,0479), and metastasis ( < 0,0001) were significant risk factors affecting overall survival (OS). Type of presentation ( = 0.0243), grading ( = 0,0055), margin ( = 0.0001), and local recurrence (0.0437) were risk factors on metastasis-free survival (MFS). Authors did not observe statistically significant risk factors for local recurrence-free survival (LRFS) and reported 55% extrapulmonary metastases and 45% pulmonary metastases.

CONCLUSION

Margins, grading, presentation, local recurrence, and metastasis were prognostic factors. Extrapulmonary metastases were more frequent in myxoid liposarcoma.

摘要

目的

作者报告了一项关于黏液样脂肪肉瘤（MLs）的回顾性研究，评估可能影响总生存期（OS）、无局部复发生存期（LRFS）、无转移生存期（MFS）的因素，并分析转移模式。

方法

分析了148例黏液样脂肪肉瘤。对转移部位进行了研究。

结果

切缘（P = 0.002）、分级（P = 0.0479）和转移情况（P < 0.0001）是影响总生存期（OS）的显著危险因素。临床表现类型（P = 0.0243）、分级（P = 0.0055）、切缘（P = 0.0001）和局部复发（P = 0.0437）是无转移生存期（MFS）的危险因素。作者未观察到无局部复发生存期（LRFS）的统计学显著危险因素，报告肺外转移率为55%，肺转移率为45%。

结论

切缘、分级、临床表现、局部复发和转移是预后因素。黏液样脂肪肉瘤中肺外转移更为常见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/8fb552c5dc82/IJSO2018-8928706.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/42b1437ba81c/IJSO2018-8928706.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/1ae5cc33247b/IJSO2018-8928706.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/a5111813a9f3/IJSO2018-8928706.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/d21e4ff225cb/IJSO2018-8928706.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/67f3d603fa1b/IJSO2018-8928706.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/8fb552c5dc82/IJSO2018-8928706.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/42b1437ba81c/IJSO2018-8928706.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/1ae5cc33247b/IJSO2018-8928706.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/a5111813a9f3/IJSO2018-8928706.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/d21e4ff225cb/IJSO2018-8928706.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/67f3d603fa1b/IJSO2018-8928706.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a4/6011058/8fb552c5dc82/IJSO2018-8928706.006.jpg

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