Harris Emily Ann, Castillon Rafael Garza, Bhakta Priya
Amita Saint Joseph Hospital, 2900 N Lakeshore Drive, Chicago, IL, USA.
J Surg Case Rep. 2020 Aug 24;2020(8):rjaa137. doi: 10.1093/jscr/rjaa137. eCollection 2020 Aug.
Hepatic artery infusion pump chemotherapy (HAIPC) for colorectal liver metastasis (CRLM) is a new technique in the treatment of CRLM, whose side effects are not well studied. Case Report: This paper aims to understand the side effect profile of HAIPC as it relates to recurrent pleural effusions. This is a case report of a 48-year-old male with CRLM being treated with HAIPC, who presents with recurrent pleural effusions found to be benign/transudative after right-side video-assisted thoracoscopic surgery. Discussion: This study suggests that HAIPC causes recurrent sympathetic pleural effusions as a side effect of the perihepatic inflammation of the localized chemotherapy treatment. Furthermore, we question if sympathetic pleural effusions are a prelude to hepatic toxicity from HAIPC. Lastly, this paper aims to guide the differential diagnosis of pleural effusions in the cancer patient being treated with HAIPC.
肝动脉灌注泵化疗（HAIPC）用于治疗结直肠癌肝转移（CRLM）是一种新技术，其副作用尚未得到充分研究。病例报告：本文旨在了解HAIPC与复发性胸腔积液相关的副作用情况。这是一例48岁患有CRLM的男性接受HAIPC治疗的病例报告，该患者在右侧电视辅助胸腔镜手术后出现复发性胸腔积液，经检查为良性/漏出性。讨论：本研究表明，HAIPC作为局部化疗治疗肝周炎症的副作用，可导致复发性交感神经源性胸腔积液。此外，我们质疑交感神经源性胸腔积液是否是HAIPC导致肝毒性的前奏。最后，本文旨在指导接受HAIPC治疗的癌症患者胸腔积液的鉴别诊断。
