Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA.
Biospherix, Lacona, New York, USA.
Stem Cells Transl Med. 2021 Jan;10(1):5-13. doi: 10.1002/sctm.20-0245. Epub 2020 Aug 27.
This perspective from a Regenerative Medicine Manufacturing Society working group highlights regenerative medicine therapeutic opportunities for fighting COVID-19. This article addresses why SARS-CoV-2 is so different from other viruses and how regenerative medicine is poised to deliver new therapeutic opportunities to battle COVID-19. We describe animal models that depict the mechanism of action for COVID-19 and that may help identify new treatments. Additionally, organoid platforms that can recapitulate some of the physiological properties of human organ systems, such as the lungs and the heart, are discussed as potential platforms that may prove useful in rapidly screening new drugs and identifying at-risk patients. This article critically evaluates some of the promising regenerative medicine-based therapies for treating COVID-19 and presents some of the collective technologies and resources that the scientific community currently has available to confront this pandemic.
这篇来自再生医学制造学会工作组的观点文章重点介绍了再生医学在对抗 COVID-19 方面的治疗机会。本文探讨了为什么 SARS-CoV-2 与其他病毒如此不同，以及再生医学如何准备为对抗 COVID-19 提供新的治疗机会。我们描述了描绘 COVID-19 作用机制的动物模型，这些模型可能有助于识别新的治疗方法。此外，还讨论了能够再现人类器官系统（如肺和心脏）某些生理特性的类器官平台，这些平台可能被证明在快速筛选新药和识别高危患者方面非常有用。本文批判性地评估了一些有前途的基于再生医学的治疗 COVID-19 的方法，并介绍了科学界目前可用于应对这一大流行病的一些集体技术和资源。
