Section of Infectious Diseases, Department of Mental health and Public Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
J Med Virol. 2021 Mar;93(3):1276-1287. doi: 10.1002/jmv.26470. Epub 2020 Oct 10.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has rapidly spread throughout the world since December 2019 to become a global public health emergency for the elevated deaths and hospitalizations in Intensive Care Units. The severity spectrum of SARS-CoV-2 pneumonia ranges from mild to severe clinical conditions. The clinical course of SARS-CoV-2 disease is correlated with multiple factors including host characteristics (genetics, immune status, age, and general health), viral load and, above all, the host distribution of the airways and lungs of the viral receptor cells. In this review, we will briefly summarize the current knowledge of the characteristics and management of coronavirus disease 2019-pneumonia. However, other studies are needed to better understand the pathogenetic mechanisms induced by SARS-Cov-2 infection, and to evaluate the long-term consequences of the virus on the lungs.
严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)自 2019 年 12 月以来在全球迅速传播,成为全球公共卫生紧急事件,重症患者的死亡率和住院率居高不下。SARS-CoV-2 肺炎的严重程度范围从轻度到严重的临床情况。SARS-CoV-2 疾病的临床过程与多个因素相关,包括宿主特征(遗传、免疫状态、年龄和总体健康状况)、病毒载量,以及最重要的是,病毒受体细胞在气道和肺部的宿主分布。在这篇综述中,我们将简要总结目前关于 2019 年冠状病毒病肺炎的特征和管理的知识。然而,还需要其他研究来更好地了解 SARS-CoV-2 感染引起的发病机制,并评估该病毒对肺部的长期影响。