Doctor of Philosophy Program in Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.
ASEAN Cancer Epidemiology and Prevention Research Group, Khon Kaen, Thailand.
Asian Pac J Cancer Prev. 2020 Aug 1;21(8):2367-2371. doi: 10.31557/APJCP.2020.21.8.2367.
Lung cancer is a major cause of cancer death worldwide. The incidence of lung cancer in Thailand increasing, but risk factors are rarely reported.
To investigate the effect of coffee consumption on lung cancer in Thai population.
Between 1990 and 2001, lifestyle and demographic data were collected from 24,528 participants in the Khon Kaen Cohort Study (KKCS), who were followed through 2016, by linking to the Khon Kaen Population-based Cancer Registry. A total of 12,668 eligible participants (68.8% females, mean age 51.0 years at baseline) having complete datasets (239,488 person-years of follow up with 138 incident cases of lung cancer observed) were analyzed using a multi-variable adjusted Cox proportional hazard models.
Coffee consumption was associated with reduced risk for lung cancer (adj. HR = 0.54; 95% CI: 0.35-0.84) after adjusting for age and gender. Cigarette smoking (adj. HR = 2.76; 95% CI: 1.32-5.78) and family history of cancer (adj. HR = 1.65; 95% CI: 1.10-2.48) were associated with higher risk.
This study suggests coffee consumption may be a protective factor for lung cancer in among this cohort.
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肺癌是全球癌症死亡的主要原因。泰国的肺癌发病率正在上升，但很少有报道其危险因素。
研究咖啡消费对泰国人群肺癌的影响。
在 1990 年至 2001 年期间，对 24528 名参加孔敬队列研究（KKCS）的参与者进行了生活方式和人口统计学数据收集，通过与孔敬人群癌症登记处关联，对参与者进行了随访，直至 2016 年。共有 12668 名符合条件的参与者（68.8%为女性，基线时的平均年龄为 51.0 岁）具有完整的数据集（239488 人年的随访时间，观察到 138 例肺癌新发病例），使用多变量调整 Cox 比例风险模型进行分析。
在调整年龄和性别后，咖啡消费与肺癌风险降低相关（调整后的 HR = 0.54；95%CI：0.35-0.84）。吸烟（调整后的 HR = 2.76；95%CI：1.32-5.78）和癌症家族史（调整后的 HR = 1.65；95%CI：1.10-2.48）与更高的风险相关。
本研究表明，在该队列中，咖啡消费可能是肺癌的保护因素。
