Zhang Jingyu, Li Jing, Ward Jas S, Truong Khai-Nghi, Rissanen Kari, Albrecht Markus
Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.
Department of Chemistry, University of Jyvaskyla, P.O. Box 35, FIN-40014 Jyväskylä, Finland.
J Org Chem. 2020 Oct 2;85(19):12160-12174. doi: 10.1021/acs.joc.0c01373. Epub 2020 Sep 16.
A catalytic approach for the preparation of indolines by dearomatizing cyclization is presented. FeCl acts as a catalyst to afford tetracyclic 5a,6-dihydro-12-indolo[2,1-][1,3]benzoxazin-12-ones in good yields. The cyclization also proceeds with tosylamides forming C-N bonds in 53% yield.
本文提出了一种通过去芳构化环化制备二氢吲哚的催化方法。氯化铁作为催化剂，能以良好的产率得到四环5a,6-二氢-12-吲哚并[2,1-][1,3]苯并恶嗪-12-酮。该环化反应也能使对甲苯磺酰胺形成C-N键，产率为53%。
