Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Modena, Italy.
Mamata Fertility Hospital, Secunderabad, India.
Gynecol Endocrinol. 2021 Apr;37(4):372-376. doi: 10.1080/09513590.2020.1810659. Epub 2020 Aug 28.
Study the interchangeability of Roche Elecsys and Beckman Coulter Access anti-Müllerian Hormone (AMH) assays to select the gonadotropin starting dose in IVF cycles.
Patients' AMH was measured using both Elecsys and Access automated assays. AMH values were then used to calculate the FSH starting dose. The main outcome is the percentage of women that would have been stratified to a different dose of gonadotropin due to differences in AMH values from the two tests.
The Access assay systematically gives higher values compared with the Elecsys assay (slope = 0.88). For Follitropin Alfa, the difference in starting dose was > 15% in 2/113 patients, when Access AMH was used instead of Elecsys. For Follitropin Delta the difference in the starting dose was >15% in 21/113 patients when using Access AMH. When considering women with high ovarian reserve, only 4/51 would have received a Follitropin Delta dose that exceeded a 15% difference using Access AMH as a substitute for the Elecsys value.
The use of the Roche Elecsys or Beckman Coulter Access leads to modest differences in AMH values, which seem to little affect the calibration of FSH dose used for ovarian stimulation.
研究罗氏 Elecsys 和贝克曼库尔特 Access 抗缪勒管激素（AMH）检测试剂的互换性，以选择 IVF 周期中的促性腺激素起始剂量。
使用 Elecsys 和 Access 自动检测试剂测量患者的 AMH。然后，使用 AMH 值计算 FSH 起始剂量。主要结局是由于两种检测方法的 AMH 值差异，会导致多少女性被分层到不同的促性腺激素剂量。
与 Elecsys 检测试剂相比，Access 检测试剂系统地给出了更高的值（斜率=0.88）。对于 Follitropin Alfa，当使用 Access AMH 代替 Elecsys 时，有 2/113 名患者的起始剂量差异>15%。对于 Follitropin Delta，有 21/113 名患者的起始剂量差异>15%，当使用 Access AMH 时。当考虑卵巢储备功能高的女性时，只有 4/51 名患者使用 Access AMH 替代 Elecsys 值时，会接受超过 15%差异的 Follitropin Delta 剂量。
罗氏 Elecsys 或贝克曼库尔特 Access 的使用导致 AMH 值略有差异，这似乎对用于卵巢刺激的 FSH 剂量的校准影响不大。
