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同期手助腹腔镜双侧多囊肾肾切除术联合肾移植治疗巨大多囊肾患者。

Simultaneous Hand-assisted Laparoscopic Bilateral Native Nephrectomy and Kidney Transplantation for Patients With Large Polycystic Kidneys.

机构信息

William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.

William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.

出版信息

Urology. 2020 Dec;146:271-277. doi: 10.1016/j.urology.2020.06.090. Epub 2020 Aug 25.

DOI:10.1016/j.urology.2020.06.090
PMID:32858084
Abstract

OBJECTIVE

To describe our technique of simultaneous hand-assisted laparoscopic bilateral native nephrectomy (BNN) and kidney transplantation (KT) in patients with autosomal dominant polycystic kidney disease and present our experience.

MATERIALS AND METHODS

We retrospectively reviewed a cohort of adult ESRD patients with symptomatic autosomal dominant polycystic kidney disease who underwent a hand-assisted laparoscopic BNN at the time of KT. We reviewed patients' and donor characteristics, and perioperative and postoperative outcomes.

RESULTS

A total of 52 patients underwent hand-assisted laparoscopic BNN at the time of KT from January 2014 to October 2019. The median age of the recipients was 53.4 years, 57.7% were males, and the median body mass index was 29.0 kg/m. All but one received a kidney from a living donor and the majority (86.5%) were pre-emptive. One patient required a small bowel resection due to an intraoperative small bowel injury. There was no solid organ injury during the procedure. All patients showed immediate allograft function and a steady decline in serum creatinine. The median decline in the creatinine and hemoglobin on day 1 was 1.2 mg/dL (inter quartile range 0.6-2.3) and 2.2 g/dL (inter quartile range 1.4-3.0), respectively.

CONCLUSION

Simultaneous hand-assisted laparoscopic bilateral nephrectomy with KT through a modified Gibson incision is feasible and safe in the hands of an experienced laparoscopic surgeon without compromising allograft function.

摘要

目的

描述我们在常染色体显性多囊肾病患者中同时进行手助腹腔镜双侧自体肾切除术(BNN)和肾移植(KT)的技术,并介绍我们的经验。

材料与方法

我们回顾性分析了一组在 ESRD 期接受手助腹腔镜双侧自体肾切除术的常染色体显性多囊肾病成年患者,并同期进行了肾移植。我们回顾了患者和供者的特征,以及围手术期和术后的结果。

结果

2014 年 1 月至 2019 年 10 月期间,共有 52 例患者在手助腹腔镜下同期进行了双侧自体肾切除术。受者的中位年龄为 53.4 岁,57.7%为男性,中位体重指数为 29.0kg/m2。除 1 例外,所有患者均接受了活体供者的肾脏,大多数(86.5%)为预先选择的。1 例患者因术中小肠损伤而需要进行小肠切除术。手术过程中无实体器官损伤。所有患者均显示立即获得移植物功能,并出现血清肌酐稳定下降。肌酐和血红蛋白在第 1 天的中位数下降分别为 1.2mg/dL(四分位距 0.6-2.3)和 2.2g/dL(四分位距 1.4-3.0)。

结论

在手助腹腔镜下,通过改良的 Gibson 切口进行同时双侧肾切除术与 KT 在经验丰富的腹腔镜外科医生手中是可行且安全的,不会影响移植物功能。

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