Anderson J M
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.
ASAIO Trans. 1988 Apr-Jun;34(2):101-7. doi: 10.1097/00002480-198804000-00005.
The implantation of artificial organs, medical devices, or biomaterials results in injury and initiation of the inflammatory response. This inflammatory response to implants has as its components acute inflammation, chronic inflammation, foreign body reaction with granulation tissue, and macrophage and foreign body giant cell interactions. The form and topography of the surface of the artificial organ, medical device, prosthesis, or biomaterial can determine the composition of the foreign body reaction. The normal foreign body reaction consists of macrophages and foreign body giant cells at the surface of the implant with subjacent fibroblastic proliferation and collagen deposition, and capillary formation. Macrophages play a pivotal role in the response of tissue to implants. An hypothesis on the role of complement activation and complement-mediated cellular adhesion to implant surfaces has been presented. Macrophage adhesion and subsequent activation leading to cell-mediator and cell-cell communication is described.
人工器官、医疗设备或生物材料的植入会导致损伤并引发炎症反应。对植入物的这种炎症反应包括急性炎症、慢性炎症、伴有肉芽组织的异物反应以及巨噬细胞与异物巨细胞的相互作用。人工器官、医疗设备、假体或生物材料表面的形态和形貌可决定异物反应的组成。正常的异物反应包括植入物表面的巨噬细胞和异物巨细胞，其下方有成纤维细胞增殖、胶原沉积以及毛细血管形成。巨噬细胞在组织对植入物的反应中起关键作用。有人提出了关于补体激活以及补体介导的细胞黏附于植入物表面的作用的假说。文中描述了巨噬细胞的黏附以及随后导致细胞介质和细胞间通讯的激活过程。
