Department of Bioengineering, University of Texas at Dallas (UTD), 800 W. Campbell Rd, Richardson, TX, 75080, USA.
School of Podiatric Medicine, The University of Texas Rio Grande Valley, Harlingen, TX, 78550, USA.
Sci Rep. 2024 Jul 16;14(1):16441. doi: 10.1038/s41598-024-66353-x.
Cement mediated peri-implantitis accounts for 1.9-75% of dental implant failures associated with peri-implant diseases. This study evaluated the biological impact of dental cements on osseointegrated implants using Lewis rats. Twenty-two rats were distributed into 6 groups: negative control (NC) soft diet (SD), and hard diet (HD); positive control SD and HD (n = 3); Implant + bio-ceramic Cement (BC) SD and HD which included contralateral Sham sites (n = 5). Titanium implants were placed on either side of the maxillae and allowed to heal for 14 days. Later, both sides of experimental groups underwent a re-entry surgery to simulate clinical cementation. The right side received 0.60 mg of BC. At 14 days post cement application, maxillae were harvested for clinical, microtomographic, and histological evaluations. Clinical and microtomographic evaluations indicated evidence of extensive inflammation and circumferential bone resorption around BC implants in comparison to NC. Histology revealed cement particles surrounded by inflammatory infiltrate in the implant area accompanied by biofilm for SD groups. Both sides of BC indicated intensive bone resorption accompanied by signs of osteolysis when compared to NC. Cemented groups depicted significantly lower bone to implant contact when compared to NC. In conclusion, residual cement extravasation negatively impacted osseointegrated implants after re-entry surgeries.
水泥介导的种植体周围炎占与种植体周围疾病相关的种植体失败的 1.9-75%。本研究使用 Lewis 大鼠评估了牙科水泥对骨整合种植体的生物学影响。22 只大鼠分为 6 组：阴性对照组（NC）软饮食（SD）和硬饮食（HD）；阳性对照组 SD 和 HD（n=3）；种植体+生物陶瓷水泥（BC）SD 和 HD，其中包括对侧 Sham 部位（n=5）。钛种植体被放置在上颌骨的两侧，并允许愈合 14 天。之后，实验组的两侧都进行了再进入手术，以模拟临床粘结。右侧接受 0.60mg 的 BC。在水泥应用后 14 天，采集上颌骨进行临床、显微 CT 和组织学评估。临床和显微 CT 评估表明，与 NC 相比，BC 种植体周围有广泛的炎症和环形骨吸收的证据。组织学显示 SD 组在种植体区域周围有水泥颗粒和炎症浸润物，伴有生物膜。与 NC 相比，BC 两侧都显示出严重的骨吸收，并伴有骨溶解的迹象。与 NC 相比，粘结组的骨-种植体接触明显降低。总之，再进入手术后，残余水泥外渗对骨整合种植体有负面影响。
