Areid Nagat, Abushahba Faleh, Riivari Sini, Närhi Timo
Department of Prosthetic Dentistry and Stomatognathic Physiology, Institute of Dentistry, University of Turku, Turku FI-20520, Finland.
Department of Biomaterials Science and Turku Clinical Biomaterial Center-TCBC, Institute of Dentistry, University of Turku, Turku FI-20520, Finland.
Int J Dent. 2024 Mar 19;2024:9079673. doi: 10.1155/2024/9079673. eCollection 2024.
Establishing a proper soft tissue adhesion around the implant abutment is essential to prevent microbial invasion, inhibit epithelial downgrowth, and obtain an optimal healing process. This systematic review aims to evaluate the real potential of TiO coating on the behavior of peri-implant soft tissue health and maintenance. A specific aim was to evaluate clinically and histologically the effect of TiO abutment coating on epithelial and connective tissue attachment. Electronic database searches were conducted from 1990 to 2023 in MEDLINE/PubMed and the Web of Science databases. In total, 15 out of 485 publications were included. Eight studies involved humans, and seven were animal studies. Exposure time ranges from 2 days to 5 years. The peri-implant soft tissue evaluations included clinical assessment (plaque index (PI), peri-implant probing pocket depth (PPD), and bleeding on probing (BoP)), histological as well as histomorphometric analysis. The Office of Health Assessment and Translation (OHAT) Risk of Bias Rating Tool for Human and Animal Studies was used to evaluate the overall quality of the studies included in the review. The results showed some variation but remained within acceptable limits. Within the limitations of this systematic review, the present findings suggest that TiO coatings seem to influence soft tissue healing. TiO-coated abutments with a roughness value between 0.2 and 0.5 m enhance soft tissue health. Sol-gel-derived TiO coatings induced better soft tissue attachment than noncoated machined abutment surfaces. The anodized titanium abutments demonstrate comparable clinical and histological outcomes to conventional machined abutments. However, there was variation among the included studies concerning TiO coating characteristics and the measured outcomes used to evaluate the soft tissue response, and therefore, quantitative analysis was not feasible. Long-term in vivo studies with standardized soft tissue analysis and coating surface parameters are necessary before a definitive conclusion can be drawn. OSF Registration No.: 10.17605/OSF.IO/E5RQV.
在种植体基台周围建立适当的软组织附着对于防止微生物入侵、抑制上皮组织向下生长以及获得最佳愈合过程至关重要。本系统评价旨在评估二氧化钛涂层对种植体周围软组织健康和维持行为的实际潜力。一个具体目标是从临床和组织学角度评估二氧化钛基台涂层对上皮和结缔组织附着的影响。在MEDLINE/PubMed和Web of Science数据库中进行了1990年至2023年的电子数据库检索。总共纳入了485篇出版物中的15篇。八项研究涉及人类，七项是动物研究。暴露时间范围从2天到5年。种植体周围软组织评估包括临床评估（菌斑指数（PI）、种植体周围探诊袋深度（PPD）和探诊出血（BoP））、组织学以及组织形态计量分析。使用健康评估与翻译办公室（OHAT）的人类和动物研究偏倚风险评级工具来评估纳入评价中的研究的整体质量。结果显示存在一些差异，但仍在可接受范围内。在本系统评价的局限性内，目前的研究结果表明二氧化钛涂层似乎会影响软组织愈合。粗糙度值在0.2至0.5μm之间的二氧化钛涂层基台可促进软组织健康。溶胶 - 凝胶法制备的二氧化钛涂层比未涂层的机械加工基台表面诱导出更好的软组织附着。阳极氧化钛基台在临床和组织学结果上与传统机械加工基台相当。然而，纳入的研究在二氧化钛涂层特性以及用于评估软组织反应的测量结果方面存在差异，因此，定量分析不可行。在得出明确结论之前，需要进行具有标准化软组织分析和涂层表面参数的长期体内研究。开放科学框架注册编号：10.17605/OSF.IO/E5RQV。
