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Ketanserin as potential additive drug to improve V/Q mismatch in COVID-19?

作者信息

Kuindersma M, Spronk P E

机构信息

Department of Intensive Care Medicine, Gelre Hospitals, Albert Schweitzerlaan 31, Apeldoorn, The Netherlands.

Expertise center for Intensive care Rehabilitation Apeldoorn (ExpIRA), Apeldoorn, The Netherlands.

出版信息

Crit Care. 2020 Aug 28;24(1):526. doi: 10.1186/s13054-020-03257-y.

DOI:10.1186/s13054-020-03257-y
PMID:32859243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7453366/
Abstract
摘要

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本文引用的文献

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COVID-19: a hypothesis regarding the ventilation-perfusion mismatch.新型冠状病毒肺炎：关于通气-灌注不匹配的一种假说。
Crit Care. 2020 Jul 6;24(1):395. doi: 10.1186/s13054-020-03125-9.
2
An Update on Current Therapeutic Drugs Treating COVID-19.治疗新型冠状病毒肺炎的当前治疗药物最新情况
Curr Pharmacol Rep. 2020;6(3):56-70. doi: 10.1007/s40495-020-00216-7. Epub 2020 May 11.
3
Effects of ketanserin on microcirculatory alterations in septic shock: An open-label pilot study.酮色林对脓毒性休克微循环改变的影响：一项开放标签的试点研究。
J Crit Care. 2015 Dec;30(6):1156-62. doi: 10.1016/j.jcrc.2015.07.004. Epub 2015 Jul 17.
4
Regulation of nitric oxide consumption by hypoxic red blood cells.缺氧红细胞对一氧化氮消耗的调节。
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12504-9. doi: 10.1073/pnas.2133409100. Epub 2003 Oct 1.
5
Ketanserin prevents platelet aggregation and endotoxin-induced pulmonary vasoconstriction.酮色林可防止血小板聚集和内毒素诱导的肺血管收缩。
Crit Care Med. 1983 Aug;11(8):606-11. doi: 10.1097/00003246-198308000-00005.