急性胰腺炎和院内 COVID-19：特定病因的宿主反应可能决定肺部损伤。
Acute pancreatitis and nosocomial COVID-19: Cause specific host responses may determine lung injury.
机构信息
Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
出版信息
Pancreatology. 2020 Oct;20(7):1258-1261. doi: 10.1016/j.pan.2020.08.008. Epub 2020 Aug 19.
BACKGROUND
Coronavirus disease 2019 (COVID-19) presents with myriad extra-pulmonary manifestation and a high mortality in patients with comorbidities. Its effect on patients with pre-existing acute pancreatitis is not known.
METHODS
We hereby, present 3 cases with severe acute pancreatitis with persistent respiratory failure who acquired nosocomial COVID-19 during their hospital stay after recovery from respiratory failure. Their clinical course is highlighted which reflects on pathophysiology of organ dysfunction in these 2 disease states.
RESULTS
None of the 3 patients with severe acute pancreatitis who developed nosocomial COVID-19 redeveloped respiratory failure due to COVID-19 despite having recently recovered from pancreatitis induced acute hypoxemic respiratory failure. Only one patient developed SARS-CoV2 induced moderate pneumonia.
CONCLUSION
These cases highlight that host responses and mechanisms of lung injury might be different in severe acute pancreatitis and COVID-19.
背景
新型冠状病毒病 2019（COVID-19）在合并症患者中具有多种肺外表现和高死亡率。其对患有既往急性胰腺炎的患者的影响尚不清楚。
方法
我们在此介绍 3 例重症急性胰腺炎患者，他们在呼吸衰竭康复后住院期间继发院内 COVID-19，持续发生呼吸衰竭。突出强调了他们的临床病程，反映了这两种疾病状态下器官功能障碍的病理生理学。
结果
尽管这 3 例重症急性胰腺炎继发院内 COVID-19 的患者最近已从胰腺炎引起的急性低氧性呼吸衰竭中康复，但均未因 COVID-19 再次发生呼吸衰竭。仅有 1 例患者发生 SARS-CoV2 引起的中度肺炎。
结论
这些病例表明，在重症急性胰腺炎和 COVID-19 中，宿主反应和肺损伤的机制可能不同。
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