切除修复交叉互补基因 1 基因型与吸烟对肺癌风险的显著交互作用。
The Significant Interaction of Excision Repair Cross-complementing Group 1 Genotypes and Smoking to Lung Cancer Risk.
机构信息
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Division of Chest Medicine, Department of Internal Medicine, Taichung Tzu Chi Hospital, Taichung, Taiwan, R.O.C.
出版信息
Cancer Genomics Proteomics. 2020 Sep-Oct;17(5):571-577. doi: 10.21873/cgp.20213.
BACKGROUND
The study aims to evaluate the contribution of excision repair cross-complementing group 1 (ERCC1), which plays an important role in genome integrity maintenance, to lung cancer risk.
MATERIALS AND METHODS
ERCC1 rs11615 and rs3212986 genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism analysis and their association with lung cancer risk was examined among 358 lung cancer patients and 716 controls.
RESULTS
The proportions of CC, CT and TT for the rs11615 genotype were 43.6%, 41.6% and 14.8% in the case group and 50.0%, 41.1% and 8.9% in the control group, respectively (p for trend=0.0082). Allelic analysis showed that ERCC1 rs11615 T-allele carriers have a 1.32-fold higher risk of lung cancer than wild-type C-allele carriers [95%confidence interval (CI)=1.09-1.60, p=0.0039]. In addition, a significant interaction between the rs11615 genotype and smoking status was observed.
CONCLUSION
The T allele of ERCC1 rs11615 jointly with smoking habits may contribute to a higher lung cancer risk in Taiwan.
背景
本研究旨在评估切除修复交叉互补基因 1（ERCC1）的作用，它在维持基因组完整性方面起着重要作用，对肺癌风险的影响。
材料与方法
通过聚合酶链反应-限制性片段长度多态性分析，鉴定 ERCC1 rs11615 和 rs3212986 基因型，并在 358 例肺癌患者和 716 例对照中检测其与肺癌风险的相关性。
结果
在病例组中，rs11615 基因型的 CC、CT 和 TT 比例分别为 43.6%、41.6%和 14.8%，对照组分别为 50.0%、41.1%和 8.9%（趋势检验 p=0.0082）。等位基因分析显示，ERCC1 rs11615 T 等位基因携带者患肺癌的风险比野生型 C 等位基因携带者高 1.32 倍（95%置信区间=1.09-1.60，p=0.0039）。此外，还观察到 rs11615 基因型与吸烟状态之间存在显著的交互作用。
结论
ERCC1 rs11615 的 T 等位基因与吸烟习惯共同作用可能导致台湾地区肺癌风险增加。
Zotero 插件