Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.
In Vivo. 2021 Jul-Aug;35(4):2041-2046. doi: 10.21873/invivo.12473.
BACKGROUND/AIM: The molecular mechanisms underlying the association between cell cycle and asthma are poorly understood, and cyclin D1 (CCND1) is found to be upregulated in asthma airway smooth muscle. We investigated whether the most frequently examined functional variants in CCND1 determine asthma susceptibility.
We genotyped 651 participants for single-nucleotide polymorphisms (SNPs) at rs9344 and rs678653 on CCND1 and assessed the association of these SNPs with asthma risk.
Significant differences were found in the distributions of genotypic (p=0.0064) and allelic (p=0.0021) frequencies of CCND1 rs9344. In addition, AG or GG carriers had 0.63- or 0.48-fold adjusted odds ratios for asthma risk (95%confidence intervals=0.48-0.92 and 0.22-0.78, respectively) than those who carried the AA wildtype.
Our results suggest that cell cycle regulation may play a role in asthma initiation and development, and the CCND1 rs9344 genotype may serve as an early detection marker for asthma.
背景/目的：细胞周期与哮喘之间关联的分子机制尚不清楚，细胞周期蛋白 D1（CCND1）在哮喘气道平滑肌中被发现上调。我们研究了 CCND1 中最常被检测到的功能变体是否决定了哮喘易感性。
我们对 651 名参与者进行了单核苷酸多态性（SNP）rs9344 和 rs678653 的基因分型，并评估了这些 SNP 与哮喘风险的关联。
CCND1 rs9344 的基因型（p=0.0064）和等位基因（p=0.0021）频率分布存在显著差异。此外，AG 或 GG 携带者的哮喘风险调整后比值比（95%置信区间=0.48-0.92 和 0.22-0.78）分别为 0.63 倍和 0.48 倍，而携带 AA 野生型的人则为 1.0。
我们的结果表明，细胞周期调控可能在哮喘的发生和发展中起作用，CCND1 rs9344 基因型可能作为哮喘的早期检测标志物。
