Department of Neurology, Guangdong Second Provincial General Hospital, Southern Medical University, 466 Middle Xingang Road, Guangzhou 510317, Guangdong, China.
Department of Infectious Diseases, Guangdong Second Provincial General Hospital, 466 Middle Xingang Road, Guangzhou 510317, Guangdong, China.
J Affect Disord. 2020 Dec 1;277:375-378. doi: 10.1016/j.jad.2020.08.037. Epub 2020 Aug 23.
The world is facing the global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). T cell-induced immune responses during acute SARS-CoV-2 infection have rarely been reported.
We use cell counting chips and PCR arrays to offer the first insights into the T cell involved in the course of acute SARS-CoV-2 infection. All consecutive patients with suspected SARS-CoV-2 infection treated at the designated hospital between January 2020 and February 2020 were recruited for the study, and cases were confirmed by real-time RT-PCR. Baseline characteristics for inpatients were prospectively collected and analyzed.
96 patients with suspected SARS-CoV-2 infection in our center were screened for inclusion in the study. The median age of the patients was 39.0 years, and 47 (49.0%) were female. Multivariate logistic regression analysis showed that only the CD4+ cell counts were significantly lower in the infection group and slightly higher in the control group. Receiver operating characteristic curve analysis showed good discrimination power between subjects with and subjects without infection.
This is a single-center study of patients with a specific ethnic background and lacks a mechanism.
These findings imply the importance of CD4+ T cells (but not CD8+ and CD3+ T cells) in SARS-CoV-2 infection associated pneumonia and indicate that CD4+ T cells might be important for the control of SARS-CoV-2.
目前，世界正面临着严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的全球传播。急性 SARS-CoV-2 感染期间 T 细胞诱导的免疫反应鲜有报道。
我们使用细胞计数芯片和 PCR 阵列，首次深入研究了急性 SARS-CoV-2 感染过程中涉及的 T 细胞。本研究纳入了 2020 年 1 月至 2 月期间在指定医院因疑似 SARS-CoV-2 感染而接受治疗的所有连续患者，并通过实时 RT-PCR 确诊。前瞻性收集和分析住院患者的基线特征。
本中心共筛查了 96 例疑似 SARS-CoV-2 感染患者，纳入研究。患者的中位年龄为 39.0 岁，47 例（49.0%）为女性。多变量逻辑回归分析显示，仅感染组的 CD4+细胞计数显著降低，而对照组的 CD4+细胞计数略高。受试者工作特征曲线分析显示，感染组和未感染组之间具有良好的区分能力。
这是一项针对特定种族背景患者的单中心研究，缺乏机制。
这些发现表明 CD4+T 细胞（而非 CD8+和 CD3+T 细胞）在 SARS-CoV-2 感染相关肺炎中具有重要作用，并表明 CD4+T 细胞可能对 SARS-CoV-2 的控制具有重要意义。
