College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, PR China.
College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, PR China.
J Pharm Biomed Anal. 2020 Oct 25;190:113548. doi: 10.1016/j.jpba.2020.113548. Epub 2020 Aug 19.
Traditional Chinese medicine (TCM) has been widely applied for the prevention and cure of various diseases for centuries. Ingredient with pharmacological activity is the key to the application of TCM. Hence, it is of significance to separate and detect active ingredients in TCM effectively. Micro/nanomaterial is the promising candidate for adsorption and sensing due to its unique physical and chemical properties. For years, many efforts have been made to develop functional micro/nanomaterials to realize the effective adsorption or sensing of bioactive compounds in TCM. In this review, we discussed recent progresses in the application of various functional micro/nanomaterials for adsorption or detection (electrochemical detection, fluorescent detection, and colorimetric detection) of active ingredients. Based on the kind of matrix materials, micro/nano-adsorbents or sensors can be classified into following categories: metal-based micro/nanomaterials, porous materials, carbon-based materials, graphene/graphite-liked micro/nanomaterials and hybrid micro/nanomaterials.
中医药在防治各种疾病方面已有数百年的广泛应用。具有药理活性的成分是中医药应用的关键。因此,有效地分离和检测中药中的活性成分具有重要意义。微/纳材料由于其独特的物理和化学性质,是吸附和传感的有前途的候选材料。多年来,人们致力于开发功能微/纳材料,以实现对中药中生物活性化合物的有效吸附或传感。在这篇综述中,我们讨论了各种功能微/纳材料在中药活性成分的吸附或检测(电化学检测、荧光检测和比色检测)方面的最新进展。根据基质材料的种类,微/纳米吸附剂或传感器可分为以下几类:基于金属的微/纳米材料、多孔材料、碳基材料、石墨烯/类石墨微/纳米材料和杂化微/纳米材料。