焦虑和抑郁对青光眼疑似患者发展为青光眼的影响。
Impact of anxiety and depression on progression to glaucoma among glaucoma suspects.
作者信息
Berchuck Samuel, Jammal Alessandro, Mukherjee Sayan, Somers Tamara, Medeiros Felipe A
机构信息
Statistical Science and Forge, Duke University, Durham, North Carolina, USA.
Ophthalmology, Duke University, Durham, North Carolina, USA.
出版信息
Br J Ophthalmol. 2021 Sep;105(9):1244-1249. doi: 10.1136/bjophthalmol-2020-316617. Epub 2020 Aug 29.
AIMS
To assess the impact of anxiety and depression in the risk of converting to glaucoma in a cohort of glaucoma suspects followed over time.
METHODS
The study included a retrospective cohort of subjects with diagnosis of glaucoma suspect at baseline, extracted from the Duke Glaucoma Registry. The presence of anxiety and depression was defined based on electronic health records billing codes, medical history and problem list. Univariable and multivariable Cox proportional hazards models were used to obtain HRs for the risk of converting to glaucoma over time. Multivariable models were adjusted for age, gender, race, intraocular pressure measurements over time and disease severity at baseline.
RESULTS
A total of 3259 glaucoma suspects followed for an average of 3.60 (2.05) years were included in our cohort, of which 911 (28%) were diagnosed with glaucoma during follow-up. Prevalence of anxiety and depression were 32% and 33%, respectively. Diagnoses of anxiety, or concomitant anxiety and depression were significantly associated with risk of converting to glaucoma over time, with adjusted HRs (95% CI) of 1.16 (1.01, 1.33) and 1.27 (1.07, 1.50), respectively.
CONCLUSION
A history of anxiety or both anxiety and depression in glaucoma suspects was associated with developing glaucoma during follow-up.
目的
评估焦虑和抑郁对一组随时间推移的青光眼疑似患者转化为青光眼风险的影响。
方法
该研究纳入了一个回顾性队列，这些受试者在基线时被诊断为青光眼疑似患者，数据来自杜克青光眼登记处。焦虑和抑郁的存在是根据电子健康记录计费代码、病史和问题清单来定义的。使用单变量和多变量Cox比例风险模型来获取随时间转化为青光眼风险的风险比（HRs）。多变量模型对年龄、性别、种族、随时间的眼压测量值以及基线时的疾病严重程度进行了调整。
结果
我们的队列中共有3259名青光眼疑似患者，平均随访3.60（2.05）年，其中911名（28%）在随访期间被诊断为青光眼。焦虑和抑郁的患病率分别为32%和33%。焦虑诊断或同时存在焦虑和抑郁与随时间转化为青光眼的风险显著相关，调整后的风险比（95%置信区间）分别为1.16（1.01，1.33）和1.27（1.07，1.50）。
结论
青光眼疑似患者的焦虑病史或焦虑与抑郁并存与随访期间发生青光眼有关。
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