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一株缺乏线粒体钙转运调节剂 MICU 的突变株显示出代谢物图谱的改变。

An mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile.

机构信息

Departamento de Bioquímica, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México.

Red de Apoyo a la Investigación, Coordinación de la Investigación Científica-UNAM, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

出版信息

Plant Signal Behav. 2023 Dec 31;18(1):2271799. doi: 10.1080/15592324.2023.2271799. Epub 2023 Oct 25.

DOI:10.1080/15592324.2023.2271799
PMID:37879964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10601504/
Abstract

Plant metabolism is constantly changing and requires input signals for efficient regulation. The mitochondrial calcium uniporter (MCU) couples organellar and cytoplasmic calcium oscillations leading to oxidative metabolism regulation in a vast array of species. In , genetic deletion of AtMICU leads to altered mitochondrial calcium handling and ultrastructure. Here we aimed to further assess the consequences upon genetic deletion of AtMICU. Our results confirm that AtMICU safeguards intracellular calcium transport associated with carbohydrate, amino acid, and phytol metabolism modifications. The implications of such alterations are discussed.

摘要

植物代谢是不断变化的，需要输入信号来进行有效的调节。线粒体钙单向转运体（MCU）耦联细胞器和细胞质钙振荡，导致众多物种的氧化代谢调节。在，AtMICU 的基因缺失导致线粒体钙处理和超微结构改变。在这里，我们旨在进一步评估 AtMICU 基因缺失的后果。我们的结果证实，AtMICU 可保护与碳水化合物、氨基酸和植醇代谢改变相关的细胞内钙转运。讨论了这种改变的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c897/10601504/ca509a91ac34/KPSB_A_2271799_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c897/10601504/87893d65b99e/KPSB_A_2271799_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c897/10601504/ca8b662a3082/KPSB_A_2271799_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c897/10601504/db06cd0bbeff/KPSB_A_2271799_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c897/10601504/d4fbb6f8bf57/KPSB_A_2271799_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c897/10601504/ca509a91ac34/KPSB_A_2271799_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c897/10601504/87893d65b99e/KPSB_A_2271799_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c897/10601504/ca8b662a3082/KPSB_A_2271799_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c897/10601504/db06cd0bbeff/KPSB_A_2271799_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c897/10601504/d4fbb6f8bf57/KPSB_A_2271799_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c897/10601504/ca509a91ac34/KPSB_A_2271799_F0005_OC.jpg

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