Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, Massachusetts, USA.
AIDS Res Hum Retroviruses. 2020 Dec;36(12):969-972. doi: 10.1089/AID.2020.0116. Epub 2020 Sep 28.
Natural killer (NK) cells provide some of the earliest immune responses to infection, but when viruses manipulate or perturb the immune environment to alter NK cell function, this places the host at a disadvantage. Indeed, others and we observe that in the context of HIV/simian immunodeficiency virus (SIV) infection, although NK cells are not infected, they can become dysfunctional over time. Several studies have characterized protein and transcriptional profiles of NK cells during HIV/SIV infection, but none have examined whether the production of alternative transcripts and corresponding isoforms is modulated. This phenomenon occurs broadly in normal biology and in other disease states, and could provide a novel avenue of investigation that may yield better targets to restore or augment NK cell responses to HIV/SIV. Herein, we briefly summarize published and new data that may provide a perspective on how to target NK cell splice variants.
自然杀伤 (NK) 细胞提供了对感染的一些最早的免疫反应，但当病毒操纵或扰乱免疫环境以改变 NK 细胞功能时，这会使宿主处于劣势。事实上，其他人（包括我们）观察到，在 HIV/猴免疫缺陷病毒 (SIV) 感染的情况下，尽管 NK 细胞未被感染，但它们随着时间的推移可能会变得功能失调。已经有几项研究描述了 HIV/SIV 感染期间 NK 细胞的蛋白质和转录谱，但没有一项研究检查替代转录本和相应同工型的产生是否受到调节。这种现象在正常生物学和其他疾病状态中广泛存在，可能为研究提供新的途径，从而找到更好的靶点来恢复或增强 NK 细胞对 HIV/SIV 的反应。在此，我们简要总结了已发表和新的数据，这些数据可能为靶向 NK 细胞剪接变异体提供了一个视角。
